Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases

Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular diseases. However, achieving the expected therapeutic efficacy is difficult using direct administration of NO donors....

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Detalles Bibliográficos
Autores principales: Zhu, Jinqiang, Song, Wanshan, Li, Lin, Fan, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802712/
https://www.ncbi.nlm.nih.gov/pubmed/27000187
http://dx.doi.org/10.1186/s13041-016-0211-9
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author Zhu, Jinqiang
Song, Wanshan
Li, Lin
Fan, Xiang
author_facet Zhu, Jinqiang
Song, Wanshan
Li, Lin
Fan, Xiang
author_sort Zhu, Jinqiang
collection PubMed
description Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular diseases. However, achieving the expected therapeutic efficacy is difficult using direct administration of NO donors. Therefore, endothelial nitric oxide synthase (eNOS) becomes a potential therapeutic target for cerebrovascular diseases. This review summarizes the current evidence supporting the importance of CBF to cerebrovascular function, and the roles of NO and eNOS in CBF regulation.
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spelling pubmed-48027122016-03-22 Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases Zhu, Jinqiang Song, Wanshan Li, Lin Fan, Xiang Mol Brain Review Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular diseases. However, achieving the expected therapeutic efficacy is difficult using direct administration of NO donors. Therefore, endothelial nitric oxide synthase (eNOS) becomes a potential therapeutic target for cerebrovascular diseases. This review summarizes the current evidence supporting the importance of CBF to cerebrovascular function, and the roles of NO and eNOS in CBF regulation. BioMed Central 2016-03-22 /pmc/articles/PMC4802712/ /pubmed/27000187 http://dx.doi.org/10.1186/s13041-016-0211-9 Text en © Zhu et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhu, Jinqiang
Song, Wanshan
Li, Lin
Fan, Xiang
Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases
title Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases
title_full Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases
title_fullStr Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases
title_full_unstemmed Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases
title_short Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases
title_sort endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802712/
https://www.ncbi.nlm.nih.gov/pubmed/27000187
http://dx.doi.org/10.1186/s13041-016-0211-9
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AT lilin endothelialnitricoxidesynthaseapotentialtherapeutictargetforcerebrovasculardiseases
AT fanxiang endothelialnitricoxidesynthaseapotentialtherapeutictargetforcerebrovasculardiseases

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