Prevention of copper-induced cell death by GC-rich DNA oligomers in murine macrophage-like RAW264.7 cells

Impact of redox active transition metals on activation of cell death signaling in plant cells have been documented to date. We have recently reported that GC-rich DNA oligomers with high affinity for binding of copper and catalytic activity for removal of ROS as novel plant cell-protecting agents. H...

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Autores principales: Matsushita, Sakiko, Mochizuki, Shinichi, Sakurai, Kazuo, Kawano, Tomonori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Article Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802767/
https://www.ncbi.nlm.nih.gov/pubmed/27066170
http://dx.doi.org/10.1080/19420889.2015.1017173
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author Matsushita, Sakiko
Mochizuki, Shinichi
Sakurai, Kazuo
Kawano, Tomonori
author_facet Matsushita, Sakiko
Mochizuki, Shinichi
Sakurai, Kazuo
Kawano, Tomonori
author_sort Matsushita, Sakiko
collection PubMed
description Impact of redox active transition metals on activation of cell death signaling in plant cells have been documented to date. We have recently reported that GC-rich DNA oligomers with high affinity for binding of copper and catalytic activity for removal of ROS as novel plant cell-protecting agents. Here, we show that similar DNA oligomers protect the mouse macrophage-like RAW264.7 cells from copper-induced cell death, suggesting that the phenomenon firstly observed in plant model can be expanded to a wider range of cells and/or organisms including mammalian cells.
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spelling pubmed-48027672016-04-08 Prevention of copper-induced cell death by GC-rich DNA oligomers in murine macrophage-like RAW264.7 cells Matsushita, Sakiko Mochizuki, Shinichi Sakurai, Kazuo Kawano, Tomonori Commun Integr Biol Article Addendum Impact of redox active transition metals on activation of cell death signaling in plant cells have been documented to date. We have recently reported that GC-rich DNA oligomers with high affinity for binding of copper and catalytic activity for removal of ROS as novel plant cell-protecting agents. Here, we show that similar DNA oligomers protect the mouse macrophage-like RAW264.7 cells from copper-induced cell death, suggesting that the phenomenon firstly observed in plant model can be expanded to a wider range of cells and/or organisms including mammalian cells. Taylor & Francis 2015-11-09 /pmc/articles/PMC4802767/ /pubmed/27066170 http://dx.doi.org/10.1080/19420889.2015.1017173 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Article Addendum
Matsushita, Sakiko
Mochizuki, Shinichi
Sakurai, Kazuo
Kawano, Tomonori
Prevention of copper-induced cell death by GC-rich DNA oligomers in murine macrophage-like RAW264.7 cells
title Prevention of copper-induced cell death by GC-rich DNA oligomers in murine macrophage-like RAW264.7 cells
title_full Prevention of copper-induced cell death by GC-rich DNA oligomers in murine macrophage-like RAW264.7 cells
title_fullStr Prevention of copper-induced cell death by GC-rich DNA oligomers in murine macrophage-like RAW264.7 cells
title_full_unstemmed Prevention of copper-induced cell death by GC-rich DNA oligomers in murine macrophage-like RAW264.7 cells
title_short Prevention of copper-induced cell death by GC-rich DNA oligomers in murine macrophage-like RAW264.7 cells
title_sort prevention of copper-induced cell death by gc-rich dna oligomers in murine macrophage-like raw264.7 cells
topic Article Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802767/
https://www.ncbi.nlm.nih.gov/pubmed/27066170
http://dx.doi.org/10.1080/19420889.2015.1017173
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