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Circadian light-input pathways in Drosophila
Light is the most important environmental cue to entrain the circadian clock in most animals. In the fruit fly Drosophila melanogaster, the light entrainment mechanisms of the clock have been well-studied. The Drosophila brain contains approximately 150 neurons that rhythmically express circadian cl...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802797/ https://www.ncbi.nlm.nih.gov/pubmed/27066180 http://dx.doi.org/10.1080/19420889.2015.1102805 |
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author | Yoshii, Taishi Hermann-Luibl, Christiane Helfrich-Förster, Charlotte |
author_facet | Yoshii, Taishi Hermann-Luibl, Christiane Helfrich-Förster, Charlotte |
author_sort | Yoshii, Taishi |
collection | PubMed |
description | Light is the most important environmental cue to entrain the circadian clock in most animals. In the fruit fly Drosophila melanogaster, the light entrainment mechanisms of the clock have been well-studied. The Drosophila brain contains approximately 150 neurons that rhythmically express circadian clock genes. These neurons are called “clock neurons” and control behavioral activity rhythms. Many clock neurons express the Cryptochrome (CRY) protein, which is sensitive to UV and blue light, and thus enables clock neurons deep in the brain to directly perceive light. In addition to the CRY protein, external photoreceptors in the Drosophila eyes play an important role in circadian light-input pathways. Recent studies have provided new insights into the mechanisms that integrate these light inputs into the circadian network of the brain. In this review, we will summarize the current knowledge on the light entrainment pathways in the Drosophila circadian clock. |
format | Online Article Text |
id | pubmed-4802797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-48027972016-04-08 Circadian light-input pathways in Drosophila Yoshii, Taishi Hermann-Luibl, Christiane Helfrich-Förster, Charlotte Commun Integr Biol Mini-Review Light is the most important environmental cue to entrain the circadian clock in most animals. In the fruit fly Drosophila melanogaster, the light entrainment mechanisms of the clock have been well-studied. The Drosophila brain contains approximately 150 neurons that rhythmically express circadian clock genes. These neurons are called “clock neurons” and control behavioral activity rhythms. Many clock neurons express the Cryptochrome (CRY) protein, which is sensitive to UV and blue light, and thus enables clock neurons deep in the brain to directly perceive light. In addition to the CRY protein, external photoreceptors in the Drosophila eyes play an important role in circadian light-input pathways. Recent studies have provided new insights into the mechanisms that integrate these light inputs into the circadian network of the brain. In this review, we will summarize the current knowledge on the light entrainment pathways in the Drosophila circadian clock. Taylor & Francis 2015-12-04 /pmc/articles/PMC4802797/ /pubmed/27066180 http://dx.doi.org/10.1080/19420889.2015.1102805 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Mini-Review Yoshii, Taishi Hermann-Luibl, Christiane Helfrich-Förster, Charlotte Circadian light-input pathways in Drosophila |
title | Circadian light-input pathways in Drosophila |
title_full | Circadian light-input pathways in Drosophila |
title_fullStr | Circadian light-input pathways in Drosophila |
title_full_unstemmed | Circadian light-input pathways in Drosophila |
title_short | Circadian light-input pathways in Drosophila |
title_sort | circadian light-input pathways in drosophila |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802797/ https://www.ncbi.nlm.nih.gov/pubmed/27066180 http://dx.doi.org/10.1080/19420889.2015.1102805 |
work_keys_str_mv | AT yoshiitaishi circadianlightinputpathwaysindrosophila AT hermannluiblchristiane circadianlightinputpathwaysindrosophila AT helfrichforstercharlotte circadianlightinputpathwaysindrosophila |