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Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases
BACKGROUND: Assays of molecular biomarkers in urine are non-invasive compared to other body fluids and can be easily repeated. Based on the hypothesis that the secreted markers from the diseased organs may locally release into the body fluid in the vicinity of the injury, urine-based assays have bee...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802825/ https://www.ncbi.nlm.nih.gov/pubmed/27000794 http://dx.doi.org/10.1186/s12894-016-0129-7 |
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author | Chen, Zhaohui Kim, Jayoung |
author_facet | Chen, Zhaohui Kim, Jayoung |
author_sort | Chen, Zhaohui |
collection | PubMed |
description | BACKGROUND: Assays of molecular biomarkers in urine are non-invasive compared to other body fluids and can be easily repeated. Based on the hypothesis that the secreted markers from the diseased organs may locally release into the body fluid in the vicinity of the injury, urine-based assays have been considered beneficial to monitoring bladder health and urological diseases. The urine proteome is much less complex than the serum and tissues, but nevertheless can contain biomarkers for diagnosis and prognosis of diseases. The urine metabolome has a much higher number and concentration of low-molecular metabolites than the serum or tissues, with a far lower lipid concentration, yet informs directly about dietary and microbial metabolism. DISCUSSION: We here discuss the use of mass spectrometry-based proteomics and metabolomics for urine biomarker assays, specifically with respect to the underlying mechanisms that trigger the pathological condition. CONCLUSION: Molecular biomarker profiles, based on proteomics and metabolomics studies, reliably distinguish patients from healthy controls, stratify sub-populations with respect to treatment options, and predict therapeutic response of patients with urological disease. |
format | Online Article Text |
id | pubmed-4802825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48028252016-03-22 Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases Chen, Zhaohui Kim, Jayoung BMC Urol Review BACKGROUND: Assays of molecular biomarkers in urine are non-invasive compared to other body fluids and can be easily repeated. Based on the hypothesis that the secreted markers from the diseased organs may locally release into the body fluid in the vicinity of the injury, urine-based assays have been considered beneficial to monitoring bladder health and urological diseases. The urine proteome is much less complex than the serum and tissues, but nevertheless can contain biomarkers for diagnosis and prognosis of diseases. The urine metabolome has a much higher number and concentration of low-molecular metabolites than the serum or tissues, with a far lower lipid concentration, yet informs directly about dietary and microbial metabolism. DISCUSSION: We here discuss the use of mass spectrometry-based proteomics and metabolomics for urine biomarker assays, specifically with respect to the underlying mechanisms that trigger the pathological condition. CONCLUSION: Molecular biomarker profiles, based on proteomics and metabolomics studies, reliably distinguish patients from healthy controls, stratify sub-populations with respect to treatment options, and predict therapeutic response of patients with urological disease. BioMed Central 2016-03-22 /pmc/articles/PMC4802825/ /pubmed/27000794 http://dx.doi.org/10.1186/s12894-016-0129-7 Text en © Chen and Kim. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Chen, Zhaohui Kim, Jayoung Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases |
title | Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases |
title_full | Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases |
title_fullStr | Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases |
title_full_unstemmed | Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases |
title_short | Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases |
title_sort | urinary proteomics and metabolomics studies to monitor bladder health and urological diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802825/ https://www.ncbi.nlm.nih.gov/pubmed/27000794 http://dx.doi.org/10.1186/s12894-016-0129-7 |
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