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New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis

BACKGROUND: Streptomyces albus J1074 produces glycosylated antibiotics paulomycin A, B and E that derive from chorismate and contain an isothiocyanate residue in form of paulic acid. Paulomycins biosynthesis pathway involves two glycosyltransferases, three acyltransferases, enzymes required for paul...

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Detalles Bibliográficos
Autores principales:	González, Aránzazu, Rodríguez, Miriam, Braña, Alfredo F., Méndez, Carmen, Salas, José A., Olano, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802897/ https://www.ncbi.nlm.nih.gov/pubmed/27001601 http://dx.doi.org/10.1186/s12934-016-0452-4

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