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Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity

BACKGROUND: Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA methyltransferase. No X-ray structure is available for the complex of Dnmt3a wit...

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Detalles Bibliográficos
Autores principales:	Lukashevich, Olga V., Cherepanova, Natalia A., Jurkovska, Renata Z., Jeltsch, Albert, Gromova, Elizaveta S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802922/ https://www.ncbi.nlm.nih.gov/pubmed/27001594 http://dx.doi.org/10.1186/s12858-016-0064-y

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