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Quality Issues of Research Antibodies

According to several recent studies, an unexpectedly high number of landmark papers seem to be not reproducible by independent laboratories. Nontherapeutic antibodies used for research, diagnostic, food analytical, environmental, and other purposes play a significant role in this matter. Although so...

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Detalles Bibliográficos
Autor principal: Weller, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803150/
https://www.ncbi.nlm.nih.gov/pubmed/27013861
http://dx.doi.org/10.4137/ACI.S31614
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author Weller, Michael G.
author_facet Weller, Michael G.
author_sort Weller, Michael G.
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description According to several recent studies, an unexpectedly high number of landmark papers seem to be not reproducible by independent laboratories. Nontherapeutic antibodies used for research, diagnostic, food analytical, environmental, and other purposes play a significant role in this matter. Although some papers have been published offering suggestions to improve the situation, they do not seem to be comprehensive enough to cover the full complexity of this issue. In addition, no obvious improvements could be noticed in the field as yet. This article tries to consolidate the remarkable variety of conclusions and suggested activities into a more coherent conception. It is concluded that funding agencies and journal publishers need to take first and immediate measures to resolve these problems and lead the way to a more sustainable way of bioanalytical research, on which all can rely with confidence.
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spelling pubmed-48031502016-03-24 Quality Issues of Research Antibodies Weller, Michael G. Anal Chem Insights Review According to several recent studies, an unexpectedly high number of landmark papers seem to be not reproducible by independent laboratories. Nontherapeutic antibodies used for research, diagnostic, food analytical, environmental, and other purposes play a significant role in this matter. Although some papers have been published offering suggestions to improve the situation, they do not seem to be comprehensive enough to cover the full complexity of this issue. In addition, no obvious improvements could be noticed in the field as yet. This article tries to consolidate the remarkable variety of conclusions and suggested activities into a more coherent conception. It is concluded that funding agencies and journal publishers need to take first and immediate measures to resolve these problems and lead the way to a more sustainable way of bioanalytical research, on which all can rely with confidence. Libertas Academica 2016-03-20 /pmc/articles/PMC4803150/ /pubmed/27013861 http://dx.doi.org/10.4137/ACI.S31614 Text en © 2016 the authors, publisher and licensee Libertas Academica Limited This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Review
Weller, Michael G.
Quality Issues of Research Antibodies
title Quality Issues of Research Antibodies
title_full Quality Issues of Research Antibodies
title_fullStr Quality Issues of Research Antibodies
title_full_unstemmed Quality Issues of Research Antibodies
title_short Quality Issues of Research Antibodies
title_sort quality issues of research antibodies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803150/
https://www.ncbi.nlm.nih.gov/pubmed/27013861
http://dx.doi.org/10.4137/ACI.S31614
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