Glutathione S Transferases Polymorphisms Are Independent Prognostic Factors in Lupus Nephritis Treated with Cyclophosphamide

OBJECTIVE: To investigate association between genetic polymorphisms of GST, CYP and renal outcome or occurrence of adverse drug reactions (ADRs) in lupus nephritis (LN) treated with cyclophosphamide (CYC). CYC, as a pro-drug, requires bioactivation through multiple hepatic cytochrome P450s and gluta...

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Detalles Bibliográficos
Autores principales: Audemard-Verger, Alexandra, Martin Silva, Nicolas, Verstuyft, Céline, Costedoat-Chalumeau, Nathalie, Hummel, Aurélie, Le Guern, Véronique, Sacré, Karim, Meyer, Olivier, Daugas, Eric, Goujard, Cécile, Sultan, Audrey, Lobbedez, Thierry, Galicier, Lionel, Pourrat, Jacques, Le Hello, Claire, Godin, Michel, Morello, Rémy, Lambert, Marc, Hachulla, Eric, Vanhille, Philippe, Queffeulou, Guillaume, Potier, Jacky, Dion, Jean-Jacques, Bataille, Pierre, Chauveau, Dominique, Moulis, Guillaume, Farge-Bancel, Dominique, Duhaut, Pierre, Saint-Marcoux, Bernadette, Deroux, Alban, Manuzak, Jennifer, Francès, Camille, Aumaitre, Olivier, Bezanahary, Holy, Becquemont, Laurent, Bienvenu, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803192/
https://www.ncbi.nlm.nih.gov/pubmed/27002825
http://dx.doi.org/10.1371/journal.pone.0151696

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