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Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type

BACKGROUND: Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL) is an invasive lymphoid malignancy with unfavorable survival, for which a prognostic model has not yet been validated. We hypothesized that serum apolipoprotein A-I (ApoA-I) may serve as a novel prognostic marker for ENKT...

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Autores principales: Quan, Qi, Chen, Qi, Chen, Ping, Jiang, Li, Li, Tingwei, Qiu, Huijuan, Zhang, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803244/
https://www.ncbi.nlm.nih.gov/pubmed/27051293
http://dx.doi.org/10.2147/OTT.S96549
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author Quan, Qi
Chen, Qi
Chen, Ping
Jiang, Li
Li, Tingwei
Qiu, Huijuan
Zhang, Bei
author_facet Quan, Qi
Chen, Qi
Chen, Ping
Jiang, Li
Li, Tingwei
Qiu, Huijuan
Zhang, Bei
author_sort Quan, Qi
collection PubMed
description BACKGROUND: Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL) is an invasive lymphoid malignancy with unfavorable survival, for which a prognostic model has not yet been validated. We hypothesized that serum apolipoprotein A-I (ApoA-I) may serve as a novel prognostic marker for ENKTL. PATIENTS AND METHODS: A total of 236 newly diagnosed cases of ENKTL were analyzed retrospectively. RESULTS: The optimal cutoff value for the serum ApoA-I level was determined to be 0.95 g/L. A total of 154 and 82 cases were assigned to the high and low ApoA-I groups, respectively. Patients in the low ApoA-I group tended to present with poorer clinical features, a lower complete remission rate (P=0.001), and poor median progression-free survival (P<0.001) and overall survival (P<0.001). Multivariate analysis using Cox model showed that the serum ApoA-I level was an independent prognostic marker of overall survival (P<0.001) and progression-free survival (P<0.001) for ENKTL patients. For cases in the low-risk group, as assessed by International Prognostic Index, Prognosis Index for peripheral T-cell lymphoma, unspecified, and Korean Prognostic Index, the serum ApoA-I level was able to differentiate cases with poor outcomes from cases with good outcomes. CONCLUSION: Our results showed that the baseline serum ApoA-I level was helpful for predicting ENKTL prognosis.
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spelling pubmed-48032442016-04-05 Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type Quan, Qi Chen, Qi Chen, Ping Jiang, Li Li, Tingwei Qiu, Huijuan Zhang, Bei Onco Targets Ther Original Research BACKGROUND: Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL) is an invasive lymphoid malignancy with unfavorable survival, for which a prognostic model has not yet been validated. We hypothesized that serum apolipoprotein A-I (ApoA-I) may serve as a novel prognostic marker for ENKTL. PATIENTS AND METHODS: A total of 236 newly diagnosed cases of ENKTL were analyzed retrospectively. RESULTS: The optimal cutoff value for the serum ApoA-I level was determined to be 0.95 g/L. A total of 154 and 82 cases were assigned to the high and low ApoA-I groups, respectively. Patients in the low ApoA-I group tended to present with poorer clinical features, a lower complete remission rate (P=0.001), and poor median progression-free survival (P<0.001) and overall survival (P<0.001). Multivariate analysis using Cox model showed that the serum ApoA-I level was an independent prognostic marker of overall survival (P<0.001) and progression-free survival (P<0.001) for ENKTL patients. For cases in the low-risk group, as assessed by International Prognostic Index, Prognosis Index for peripheral T-cell lymphoma, unspecified, and Korean Prognostic Index, the serum ApoA-I level was able to differentiate cases with poor outcomes from cases with good outcomes. CONCLUSION: Our results showed that the baseline serum ApoA-I level was helpful for predicting ENKTL prognosis. Dove Medical Press 2016-03-14 /pmc/articles/PMC4803244/ /pubmed/27051293 http://dx.doi.org/10.2147/OTT.S96549 Text en © 2016 Quan et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Quan, Qi
Chen, Qi
Chen, Ping
Jiang, Li
Li, Tingwei
Qiu, Huijuan
Zhang, Bei
Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type
title Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type
title_full Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type
title_fullStr Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type
title_full_unstemmed Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type
title_short Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type
title_sort decreased apolipoprotein a-i level indicates poor prognosis in extranodal natural killer/t-cell lymphoma, nasal type
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803244/
https://www.ncbi.nlm.nih.gov/pubmed/27051293
http://dx.doi.org/10.2147/OTT.S96549
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