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Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type
BACKGROUND: Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL) is an invasive lymphoid malignancy with unfavorable survival, for which a prognostic model has not yet been validated. We hypothesized that serum apolipoprotein A-I (ApoA-I) may serve as a novel prognostic marker for ENKT...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803244/ https://www.ncbi.nlm.nih.gov/pubmed/27051293 http://dx.doi.org/10.2147/OTT.S96549 |
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author | Quan, Qi Chen, Qi Chen, Ping Jiang, Li Li, Tingwei Qiu, Huijuan Zhang, Bei |
author_facet | Quan, Qi Chen, Qi Chen, Ping Jiang, Li Li, Tingwei Qiu, Huijuan Zhang, Bei |
author_sort | Quan, Qi |
collection | PubMed |
description | BACKGROUND: Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL) is an invasive lymphoid malignancy with unfavorable survival, for which a prognostic model has not yet been validated. We hypothesized that serum apolipoprotein A-I (ApoA-I) may serve as a novel prognostic marker for ENKTL. PATIENTS AND METHODS: A total of 236 newly diagnosed cases of ENKTL were analyzed retrospectively. RESULTS: The optimal cutoff value for the serum ApoA-I level was determined to be 0.95 g/L. A total of 154 and 82 cases were assigned to the high and low ApoA-I groups, respectively. Patients in the low ApoA-I group tended to present with poorer clinical features, a lower complete remission rate (P=0.001), and poor median progression-free survival (P<0.001) and overall survival (P<0.001). Multivariate analysis using Cox model showed that the serum ApoA-I level was an independent prognostic marker of overall survival (P<0.001) and progression-free survival (P<0.001) for ENKTL patients. For cases in the low-risk group, as assessed by International Prognostic Index, Prognosis Index for peripheral T-cell lymphoma, unspecified, and Korean Prognostic Index, the serum ApoA-I level was able to differentiate cases with poor outcomes from cases with good outcomes. CONCLUSION: Our results showed that the baseline serum ApoA-I level was helpful for predicting ENKTL prognosis. |
format | Online Article Text |
id | pubmed-4803244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48032442016-04-05 Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type Quan, Qi Chen, Qi Chen, Ping Jiang, Li Li, Tingwei Qiu, Huijuan Zhang, Bei Onco Targets Ther Original Research BACKGROUND: Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL) is an invasive lymphoid malignancy with unfavorable survival, for which a prognostic model has not yet been validated. We hypothesized that serum apolipoprotein A-I (ApoA-I) may serve as a novel prognostic marker for ENKTL. PATIENTS AND METHODS: A total of 236 newly diagnosed cases of ENKTL were analyzed retrospectively. RESULTS: The optimal cutoff value for the serum ApoA-I level was determined to be 0.95 g/L. A total of 154 and 82 cases were assigned to the high and low ApoA-I groups, respectively. Patients in the low ApoA-I group tended to present with poorer clinical features, a lower complete remission rate (P=0.001), and poor median progression-free survival (P<0.001) and overall survival (P<0.001). Multivariate analysis using Cox model showed that the serum ApoA-I level was an independent prognostic marker of overall survival (P<0.001) and progression-free survival (P<0.001) for ENKTL patients. For cases in the low-risk group, as assessed by International Prognostic Index, Prognosis Index for peripheral T-cell lymphoma, unspecified, and Korean Prognostic Index, the serum ApoA-I level was able to differentiate cases with poor outcomes from cases with good outcomes. CONCLUSION: Our results showed that the baseline serum ApoA-I level was helpful for predicting ENKTL prognosis. Dove Medical Press 2016-03-14 /pmc/articles/PMC4803244/ /pubmed/27051293 http://dx.doi.org/10.2147/OTT.S96549 Text en © 2016 Quan et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Quan, Qi Chen, Qi Chen, Ping Jiang, Li Li, Tingwei Qiu, Huijuan Zhang, Bei Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type |
title | Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type |
title_full | Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type |
title_fullStr | Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type |
title_full_unstemmed | Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type |
title_short | Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type |
title_sort | decreased apolipoprotein a-i level indicates poor prognosis in extranodal natural killer/t-cell lymphoma, nasal type |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803244/ https://www.ncbi.nlm.nih.gov/pubmed/27051293 http://dx.doi.org/10.2147/OTT.S96549 |
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