Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein

Prion diseases are fatal neurodegenerative disorders for which there is no effective treatment. Because the cellular prion protein (PrP(C)) is required for propagation of the infectious scrapie form of the protein, one therapeutic strategy is to reduce PrP(C) expression. Recently FK506, an inhibitor...

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Detalles Bibliográficos
Autores principales: Stocki, Pawel, Sawicki, Maxime, Mays, Charles E., Hong, Seo Jung, Chapman, Daniel C., Westaway, David, Williams, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803302/
https://www.ncbi.nlm.nih.gov/pubmed/26764098
http://dx.doi.org/10.1091/mbc.E15-10-0729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803302/
https://www.ncbi.nlm.nih.gov/pubmed/26764098
http://dx.doi.org/10.1091/mbc.E15-10-0729

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