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Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein
Prion diseases are fatal neurodegenerative disorders for which there is no effective treatment. Because the cellular prion protein (PrP(C)) is required for propagation of the infectious scrapie form of the protein, one therapeutic strategy is to reduce PrP(C) expression. Recently FK506, an inhibitor...
Autores principales: | Stocki, Pawel, Sawicki, Maxime, Mays, Charles E., Hong, Seo Jung, Chapman, Daniel C., Westaway, David, Williams, David B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803302/ https://www.ncbi.nlm.nih.gov/pubmed/26764098 http://dx.doi.org/10.1091/mbc.E15-10-0729 |
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