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Control of T cell antigen reactivity via programmed TCR downregulation

The T cell receptor (TCR) is unique in that its affinity for ligand is unknown prior to encounter and can vary by orders of magnitude. How the immune system regulates individual T cells that display highly different reactivity to antigen remains unclear. Here we identified that activated CD4(+) T ce...

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Detalles Bibliográficos
Autores principales:	Gallegos, Alena M, Xiong, Huizhong, Leiner, Ingrid M, Sušac, Bože, Glickman, Michael S, Pamer, Eric G, van Heijst, Jeroen W J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803589/ https://www.ncbi.nlm.nih.gov/pubmed/26901151 http://dx.doi.org/10.1038/ni.3386

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