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Nanoparticles: A Challenging Vehicle for Neural Stimulation
Neurostimulation represents a powerful and well-established tool for the treatment of several diseases affecting the central nervous system. Although, effective in reducing the symptoms or the progression of brain disorders, the poor accessibility of the deepest areas of the brain currently hampers...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803724/ https://www.ncbi.nlm.nih.gov/pubmed/27047327 http://dx.doi.org/10.3389/fnins.2016.00105 |
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author | Colombo, Elisabetta Feyen, Paul Antognazza, Maria Rosa Lanzani, Guglielmo Benfenati, Fabio |
author_facet | Colombo, Elisabetta Feyen, Paul Antognazza, Maria Rosa Lanzani, Guglielmo Benfenati, Fabio |
author_sort | Colombo, Elisabetta |
collection | PubMed |
description | Neurostimulation represents a powerful and well-established tool for the treatment of several diseases affecting the central nervous system. Although, effective in reducing the symptoms or the progression of brain disorders, the poor accessibility of the deepest areas of the brain currently hampers the possibility of a more specific and controlled therapeutic stimulation, depending on invasive surgical approaches and long-term stability, and biocompatibility issues. The massive research of the last decades on nanomaterials and nanoscale devices favored the development of new tools to address the limitations of the available neurostimulation approaches. This mini-review focuses on the employment of nanoparticles for the modulation of the electrophysiological activity of neuronal networks and the related transduction mechanisms underlying the nanostructure-neuron interfaces. |
format | Online Article Text |
id | pubmed-4803724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48037242016-04-04 Nanoparticles: A Challenging Vehicle for Neural Stimulation Colombo, Elisabetta Feyen, Paul Antognazza, Maria Rosa Lanzani, Guglielmo Benfenati, Fabio Front Neurosci Neuroscience Neurostimulation represents a powerful and well-established tool for the treatment of several diseases affecting the central nervous system. Although, effective in reducing the symptoms or the progression of brain disorders, the poor accessibility of the deepest areas of the brain currently hampers the possibility of a more specific and controlled therapeutic stimulation, depending on invasive surgical approaches and long-term stability, and biocompatibility issues. The massive research of the last decades on nanomaterials and nanoscale devices favored the development of new tools to address the limitations of the available neurostimulation approaches. This mini-review focuses on the employment of nanoparticles for the modulation of the electrophysiological activity of neuronal networks and the related transduction mechanisms underlying the nanostructure-neuron interfaces. Frontiers Media S.A. 2016-03-23 /pmc/articles/PMC4803724/ /pubmed/27047327 http://dx.doi.org/10.3389/fnins.2016.00105 Text en Copyright © 2016 Colombo, Feyen, Antognazza, Lanzani and Benfenati. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Colombo, Elisabetta Feyen, Paul Antognazza, Maria Rosa Lanzani, Guglielmo Benfenati, Fabio Nanoparticles: A Challenging Vehicle for Neural Stimulation |
title | Nanoparticles: A Challenging Vehicle for Neural Stimulation |
title_full | Nanoparticles: A Challenging Vehicle for Neural Stimulation |
title_fullStr | Nanoparticles: A Challenging Vehicle for Neural Stimulation |
title_full_unstemmed | Nanoparticles: A Challenging Vehicle for Neural Stimulation |
title_short | Nanoparticles: A Challenging Vehicle for Neural Stimulation |
title_sort | nanoparticles: a challenging vehicle for neural stimulation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803724/ https://www.ncbi.nlm.nih.gov/pubmed/27047327 http://dx.doi.org/10.3389/fnins.2016.00105 |
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