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Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis

The composition of the human microbiota influences tumorigenesis, notably in colorectal cancer (CRC). Pathogenic Escherichia coli possesses a variety of virulent factors, among them the Cytolethal Distending Toxin (CDT). CDT displays dual DNase and phosphatase activities and induces DNA double stran...

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Detalles Bibliográficos
Autores principales:	Graillot, Vanessa, Dormoy, Inge, Dupuy, Jacques, Shay, Jerry W., Huc, Laurence, Mirey, Gladys, Vignard, Julien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803749/ https://www.ncbi.nlm.nih.gov/pubmed/27047802 http://dx.doi.org/10.3389/fcimb.2016.00034

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