Cargando…

Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in developed countries. Recent studies indicated that the modification of gut microbiota plays an important role in the progression from simple steatosis to steatohepatitis. Epidemiological studies have demonstrated...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Yu, Wang, Hualin, Yuan, Fahu, Li, Na, Huang, Qiang, He, Lei, Wang, Limei, Liu, Zhiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804047/
https://www.ncbi.nlm.nih.gov/pubmed/27051672
http://dx.doi.org/10.1155/2016/9462571
_version_ 1782422958921220096
author Tian, Yu
Wang, Hualin
Yuan, Fahu
Li, Na
Huang, Qiang
He, Lei
Wang, Limei
Liu, Zhiguo
author_facet Tian, Yu
Wang, Hualin
Yuan, Fahu
Li, Na
Huang, Qiang
He, Lei
Wang, Limei
Liu, Zhiguo
author_sort Tian, Yu
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in developed countries. Recent studies indicated that the modification of gut microbiota plays an important role in the progression from simple steatosis to steatohepatitis. Epidemiological studies have demonstrated consumption of fish oil or perilla oil rich in n-3 polyunsaturated fatty acids (PUFAs) protects against NAFLD. However, the underlying mechanisms remain unclear. In the present study, we adopted 16s rRNA amplicon sequencing technique to investigate the impacts of fish oil and perilla oil on gut microbiomes modification in rats with high-fat diet- (HFD-) induced NAFLD. Both fish oil and perilla oil ameliorated HFD-induced hepatic steatosis and inflammation. In comparison with the low-fat control diet, HFD feeding significantly reduced the relative abundance of Gram-positive bacteria in the gut, which was slightly reversed by either fish oil or perilla oil. Additionally, fish oil and perilla oil consumption abrogated the elevated abundance of Prevotella and Escherichia in the gut from HFD fed animals. Interestingly, the relative abundance of antiobese Akkermansia was remarkably increased only in animals fed fish oil compared with HFD group. In conclusion, compared with fish oil, perilla oil has similar but slightly weaker potency against HFD-induced NAFLD and gut dysbiosis.
format Online
Article
Text
id pubmed-4804047
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-48040472016-04-05 Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis Tian, Yu Wang, Hualin Yuan, Fahu Li, Na Huang, Qiang He, Lei Wang, Limei Liu, Zhiguo Biomed Res Int Research Article Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in developed countries. Recent studies indicated that the modification of gut microbiota plays an important role in the progression from simple steatosis to steatohepatitis. Epidemiological studies have demonstrated consumption of fish oil or perilla oil rich in n-3 polyunsaturated fatty acids (PUFAs) protects against NAFLD. However, the underlying mechanisms remain unclear. In the present study, we adopted 16s rRNA amplicon sequencing technique to investigate the impacts of fish oil and perilla oil on gut microbiomes modification in rats with high-fat diet- (HFD-) induced NAFLD. Both fish oil and perilla oil ameliorated HFD-induced hepatic steatosis and inflammation. In comparison with the low-fat control diet, HFD feeding significantly reduced the relative abundance of Gram-positive bacteria in the gut, which was slightly reversed by either fish oil or perilla oil. Additionally, fish oil and perilla oil consumption abrogated the elevated abundance of Prevotella and Escherichia in the gut from HFD fed animals. Interestingly, the relative abundance of antiobese Akkermansia was remarkably increased only in animals fed fish oil compared with HFD group. In conclusion, compared with fish oil, perilla oil has similar but slightly weaker potency against HFD-induced NAFLD and gut dysbiosis. Hindawi Publishing Corporation 2016 2016-03-09 /pmc/articles/PMC4804047/ /pubmed/27051672 http://dx.doi.org/10.1155/2016/9462571 Text en Copyright © 2016 Yu Tian et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tian, Yu
Wang, Hualin
Yuan, Fahu
Li, Na
Huang, Qiang
He, Lei
Wang, Limei
Liu, Zhiguo
Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis
title Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis
title_full Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis
title_fullStr Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis
title_full_unstemmed Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis
title_short Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis
title_sort perilla oil has similar protective effects of fish oil on high-fat diet-induced nonalcoholic fatty liver disease and gut dysbiosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804047/
https://www.ncbi.nlm.nih.gov/pubmed/27051672
http://dx.doi.org/10.1155/2016/9462571
work_keys_str_mv AT tianyu perillaoilhassimilarprotectiveeffectsoffishoilonhighfatdietinducednonalcoholicfattyliverdiseaseandgutdysbiosis
AT wanghualin perillaoilhassimilarprotectiveeffectsoffishoilonhighfatdietinducednonalcoholicfattyliverdiseaseandgutdysbiosis
AT yuanfahu perillaoilhassimilarprotectiveeffectsoffishoilonhighfatdietinducednonalcoholicfattyliverdiseaseandgutdysbiosis
AT lina perillaoilhassimilarprotectiveeffectsoffishoilonhighfatdietinducednonalcoholicfattyliverdiseaseandgutdysbiosis
AT huangqiang perillaoilhassimilarprotectiveeffectsoffishoilonhighfatdietinducednonalcoholicfattyliverdiseaseandgutdysbiosis
AT helei perillaoilhassimilarprotectiveeffectsoffishoilonhighfatdietinducednonalcoholicfattyliverdiseaseandgutdysbiosis
AT wanglimei perillaoilhassimilarprotectiveeffectsoffishoilonhighfatdietinducednonalcoholicfattyliverdiseaseandgutdysbiosis
AT liuzhiguo perillaoilhassimilarprotectiveeffectsoffishoilonhighfatdietinducednonalcoholicfattyliverdiseaseandgutdysbiosis