Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model

The Hedgehog (HH) pathway has been linked to the formation of basal cell carcinoma (BCC), medulloblastoma, and other cancers. The recently approved orally active drugs vismodegib (GDC‐0449) and sonidegib (LDE–225) were not only efficacious for the treatment of advanced or metastatic BCC by antagoniz...

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Detalles Bibliográficos
Autores principales: Lauressergues, Emilie, Heusler, Peter, Lestienne, Fabrice, Troulier, David, Rauly‐Lestienne, Isabelle, Tourette, Amélie, Ailhaud, Marie‐Christine, Cathala, Claudie, Tardif, Stéphanie, Denais‐Laliève, Delphine, Calmettes, Marie‐Thérèse, Degryse, Anne‐Dominique, Dumoulin, Antoine, De Vries, Luc, Cussac, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804317/
https://www.ncbi.nlm.nih.gov/pubmed/27069629
http://dx.doi.org/10.1002/prp2.214

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