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Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients
BACKGROUND: Fetuin-A is known as a circulating inhibitor of vascular calcification. Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients is still uncertain. METHODS: In the post-hoc study, we analyzed serum fetuin-A and bio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804565/ https://www.ncbi.nlm.nih.gov/pubmed/27007989 http://dx.doi.org/10.1186/s12882-016-0245-3 |
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author | Lin, Hsin-Hung Liou, Hung-Hsiang Wu, Ming-Shiou Huang, Chiu-Ching |
author_facet | Lin, Hsin-Hung Liou, Hung-Hsiang Wu, Ming-Shiou Huang, Chiu-Ching |
author_sort | Lin, Hsin-Hung |
collection | PubMed |
description | BACKGROUND: Fetuin-A is known as a circulating inhibitor of vascular calcification. Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients is still uncertain. METHODS: In the post-hoc study, we analyzed serum fetuin-A and biochemical factors (Ca, P, i-PTH, hsCRP, TG, LDL-C) in 50 hemodialysis patients, who completed a 48-week, open-Label, controlled randomized parallel-group study. 23 patients received sevelamer and 27 patients received calcium carbonate. RESULTS: After the 48-week treatment, the sevelamer group had less serum calcium increment, less iPTH decrement, more ALK-P increment, more hsCRP decrement and more LDL-C decrement. There was no significant difference in the serum fetuin-A decrement between two groups. Decreased serum fetuin-A levels were found after 48-week treatment in both groups: from 210.61 (104.73) to 153.85 (38.64) ug/dl, P = 0.003 in sevelamer group, from 203.95 (107.87) to 170.90 (58.02) ug/mL, P =0.002 in calcium group. The decrement in serum fetuin-A (Δfetuin-A) levels was associated with ΔCa (ρ = - 0.230, P = 0.040), ΔiPTH (ρ = 0.306, P = 0.031) and Δalbumin (ρ = 0.408, P = 0.003), not associated with sevelamer use, ΔP and ΔhsCRP. CONCLUSION: After long-term sevelamer or calcium carbonate treatment, both groups of maintenance HD patients had lower serum fetuin-A levels. Serum levels of increased calcium, decreased iPTH and decreased albumin were associated with the serum fetuin-A decrement. |
format | Online Article Text |
id | pubmed-4804565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48045652016-03-24 Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients Lin, Hsin-Hung Liou, Hung-Hsiang Wu, Ming-Shiou Huang, Chiu-Ching BMC Nephrol Research Article BACKGROUND: Fetuin-A is known as a circulating inhibitor of vascular calcification. Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients is still uncertain. METHODS: In the post-hoc study, we analyzed serum fetuin-A and biochemical factors (Ca, P, i-PTH, hsCRP, TG, LDL-C) in 50 hemodialysis patients, who completed a 48-week, open-Label, controlled randomized parallel-group study. 23 patients received sevelamer and 27 patients received calcium carbonate. RESULTS: After the 48-week treatment, the sevelamer group had less serum calcium increment, less iPTH decrement, more ALK-P increment, more hsCRP decrement and more LDL-C decrement. There was no significant difference in the serum fetuin-A decrement between two groups. Decreased serum fetuin-A levels were found after 48-week treatment in both groups: from 210.61 (104.73) to 153.85 (38.64) ug/dl, P = 0.003 in sevelamer group, from 203.95 (107.87) to 170.90 (58.02) ug/mL, P =0.002 in calcium group. The decrement in serum fetuin-A (Δfetuin-A) levels was associated with ΔCa (ρ = - 0.230, P = 0.040), ΔiPTH (ρ = 0.306, P = 0.031) and Δalbumin (ρ = 0.408, P = 0.003), not associated with sevelamer use, ΔP and ΔhsCRP. CONCLUSION: After long-term sevelamer or calcium carbonate treatment, both groups of maintenance HD patients had lower serum fetuin-A levels. Serum levels of increased calcium, decreased iPTH and decreased albumin were associated with the serum fetuin-A decrement. BioMed Central 2016-03-23 /pmc/articles/PMC4804565/ /pubmed/27007989 http://dx.doi.org/10.1186/s12882-016-0245-3 Text en © Lin et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Lin, Hsin-Hung Liou, Hung-Hsiang Wu, Ming-Shiou Huang, Chiu-Ching Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients |
title | Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients |
title_full | Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients |
title_fullStr | Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients |
title_full_unstemmed | Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients |
title_short | Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients |
title_sort | factors associated with serum fetuin-a concentrations after long-term use of different phosphate binders in hemodialysis patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804565/ https://www.ncbi.nlm.nih.gov/pubmed/27007989 http://dx.doi.org/10.1186/s12882-016-0245-3 |
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