Preservation of methylated CpG dinucleotides in human CpG islands

BACKGROUND: CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic re...

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Detalles Bibliográficos
Autores principales: Panchin, Alexander Y., Makeev, Vsevolod J., Medvedeva, Yulia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804638/
https://www.ncbi.nlm.nih.gov/pubmed/27005429
http://dx.doi.org/10.1186/s13062-016-0113-x

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