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Relationship between Neck Circumference and Non-Alcoholic Fatty Liver Disease in Childhood Obesity

OBJECTIVE: The aim of this study was to establish the association between anthropometric parameters and non-alcoholic fatty liver disease (NAFLD) and to determine the most reliable measurement as a parameter in predicting NAFLD. METHODS: Two-hundred fifty-three obese children of ages 10 to 18 years...

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Autores principales: Hatipoğlu, Nihal, Doğan, Serap, Mazıcıoğlu, M. Mümtaz, Kurtoğlu, Selim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805046/
https://www.ncbi.nlm.nih.gov/pubmed/26758497
http://dx.doi.org/10.4274/jcrpe.2313
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author Hatipoğlu, Nihal
Doğan, Serap
Mazıcıoğlu, M. Mümtaz
Kurtoğlu, Selim
author_facet Hatipoğlu, Nihal
Doğan, Serap
Mazıcıoğlu, M. Mümtaz
Kurtoğlu, Selim
author_sort Hatipoğlu, Nihal
collection PubMed
description OBJECTIVE: The aim of this study was to establish the association between anthropometric parameters and non-alcoholic fatty liver disease (NAFLD) and to determine the most reliable measurement as a parameter in predicting NAFLD. METHODS: Two-hundred fifty-three obese children of ages 10 to 18 years were enrolled in this study. Anthropometric data and metabolic parameters such as fasting blood glucose, insulin and lipid levels, were measured. Liver function tests were assessed. NAFLD was determined by ultrasound. RESULTS: Most metabolic parameters and anthropometric indices were significantly higher in children with NAFLD. A univariate logistic regression analysis was performed, taking NAFLD status as the dependent variable and anthropometric parameters as the independent variables. NAFLD was affected significantly by the anthropometric values. The multiple logistic regression analysis showed that neck circumference (NC) was the only parameter which determined the risk in both genders. Each 1 cm increase in the NC increased the risk of NAFLD 1.544-fold (p<0.001, 95% confidence interval (CI): 1.357-2.214) in the boys and 1.733-fold (p=0.001, 95% CI: 1.185-2.012) in the girls. Receiver operating characteristic analysis was performed to compare the reliability of anthropometric measurements. NC was observed to be a better indicator. CONCLUSION: Measurement of the NC was shown to be associated with NAFLD in children. We suggest the use of NC as a novel, simple, practical, and reliable anthropometric index in predicting children at risk for NAFLD.
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spelling pubmed-48050462016-04-06 Relationship between Neck Circumference and Non-Alcoholic Fatty Liver Disease in Childhood Obesity Hatipoğlu, Nihal Doğan, Serap Mazıcıoğlu, M. Mümtaz Kurtoğlu, Selim J Clin Res Pediatr Endocrinol Original Article OBJECTIVE: The aim of this study was to establish the association between anthropometric parameters and non-alcoholic fatty liver disease (NAFLD) and to determine the most reliable measurement as a parameter in predicting NAFLD. METHODS: Two-hundred fifty-three obese children of ages 10 to 18 years were enrolled in this study. Anthropometric data and metabolic parameters such as fasting blood glucose, insulin and lipid levels, were measured. Liver function tests were assessed. NAFLD was determined by ultrasound. RESULTS: Most metabolic parameters and anthropometric indices were significantly higher in children with NAFLD. A univariate logistic regression analysis was performed, taking NAFLD status as the dependent variable and anthropometric parameters as the independent variables. NAFLD was affected significantly by the anthropometric values. The multiple logistic regression analysis showed that neck circumference (NC) was the only parameter which determined the risk in both genders. Each 1 cm increase in the NC increased the risk of NAFLD 1.544-fold (p<0.001, 95% confidence interval (CI): 1.357-2.214) in the boys and 1.733-fold (p=0.001, 95% CI: 1.185-2.012) in the girls. Receiver operating characteristic analysis was performed to compare the reliability of anthropometric measurements. NC was observed to be a better indicator. CONCLUSION: Measurement of the NC was shown to be associated with NAFLD in children. We suggest the use of NC as a novel, simple, practical, and reliable anthropometric index in predicting children at risk for NAFLD. Galenos Publishing 2016-03 2016-03-01 /pmc/articles/PMC4805046/ /pubmed/26758497 http://dx.doi.org/10.4274/jcrpe.2313 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hatipoğlu, Nihal
Doğan, Serap
Mazıcıoğlu, M. Mümtaz
Kurtoğlu, Selim
Relationship between Neck Circumference and Non-Alcoholic Fatty Liver Disease in Childhood Obesity
title Relationship between Neck Circumference and Non-Alcoholic Fatty Liver Disease in Childhood Obesity
title_full Relationship between Neck Circumference and Non-Alcoholic Fatty Liver Disease in Childhood Obesity
title_fullStr Relationship between Neck Circumference and Non-Alcoholic Fatty Liver Disease in Childhood Obesity
title_full_unstemmed Relationship between Neck Circumference and Non-Alcoholic Fatty Liver Disease in Childhood Obesity
title_short Relationship between Neck Circumference and Non-Alcoholic Fatty Liver Disease in Childhood Obesity
title_sort relationship between neck circumference and non-alcoholic fatty liver disease in childhood obesity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805046/
https://www.ncbi.nlm.nih.gov/pubmed/26758497
http://dx.doi.org/10.4274/jcrpe.2313
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