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Characterization of a Polyethylene Glycol-Amphotericin B Conjugate Loaded with Free AMB for Improved Antifungal Efficacy

Amphotericin B (AMB) is a highly hydrophobic antifungal, whose use is limited by its toxicity and poor solubility. To improve its solubility, AMB was reacted with a functionalized polyethylene glycol (PEG), yielding soluble complex AmB-PEG formulations that theoretically comprise of chemically conju...

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Detalles Bibliográficos
Autores principales:	Tan, Tessa Rui Min, Hoi, Kong Meng, Zhang, Peiqing, Ng, Say Kong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805162/ https://www.ncbi.nlm.nih.gov/pubmed/27008086 http://dx.doi.org/10.1371/journal.pone.0152112

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