Cargando…

A Criterion for the Complete Deposition of Magnetic Beads on the Walls of Microchannels

This paper analyzes numerical simulations of the trajectories of magnetic beads in a microchannel, with a nearby permanent cubical magnet, under different flow and magnetic conditions. Analytically derived local fluid velocities and local magnetic forces have been used to track the particles. A cent...

Descripción completa

Detalles Bibliográficos
Autor principal: Pallares, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805241/
https://www.ncbi.nlm.nih.gov/pubmed/27007336
http://dx.doi.org/10.1371/journal.pone.0151053
_version_ 1782423118198865920
author Pallares, Jordi
author_facet Pallares, Jordi
author_sort Pallares, Jordi
collection PubMed
description This paper analyzes numerical simulations of the trajectories of magnetic beads in a microchannel, with a nearby permanent cubical magnet, under different flow and magnetic conditions. Analytically derived local fluid velocities and local magnetic forces have been used to track the particles. A centered position and a lateral position of the magnet above the microchannel are considered. The computed fractions of deposited particles on the walls are compared successfully with a new theoretically derived criterion that imposes a relation between the sizes of the magnet and the microchannel and the particle Stokes and Alfvén numbers to obtain the complete deposition of the flowing particles on the wall. In the cases in which all the particles, initially distributed uniformly across the section of the microchannel, are deposited on the walls, the simulations predict the accumulation of the major part of particles on the wall closest to the magnet and near the first half of the streamwise length of the magnet.
format Online
Article
Text
id pubmed-4805241
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-48052412016-03-25 A Criterion for the Complete Deposition of Magnetic Beads on the Walls of Microchannels Pallares, Jordi PLoS One Research Article This paper analyzes numerical simulations of the trajectories of magnetic beads in a microchannel, with a nearby permanent cubical magnet, under different flow and magnetic conditions. Analytically derived local fluid velocities and local magnetic forces have been used to track the particles. A centered position and a lateral position of the magnet above the microchannel are considered. The computed fractions of deposited particles on the walls are compared successfully with a new theoretically derived criterion that imposes a relation between the sizes of the magnet and the microchannel and the particle Stokes and Alfvén numbers to obtain the complete deposition of the flowing particles on the wall. In the cases in which all the particles, initially distributed uniformly across the section of the microchannel, are deposited on the walls, the simulations predict the accumulation of the major part of particles on the wall closest to the magnet and near the first half of the streamwise length of the magnet. Public Library of Science 2016-03-23 /pmc/articles/PMC4805241/ /pubmed/27007336 http://dx.doi.org/10.1371/journal.pone.0151053 Text en © 2016 Jordi Pallares http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pallares, Jordi
A Criterion for the Complete Deposition of Magnetic Beads on the Walls of Microchannels
title A Criterion for the Complete Deposition of Magnetic Beads on the Walls of Microchannels
title_full A Criterion for the Complete Deposition of Magnetic Beads on the Walls of Microchannels
title_fullStr A Criterion for the Complete Deposition of Magnetic Beads on the Walls of Microchannels
title_full_unstemmed A Criterion for the Complete Deposition of Magnetic Beads on the Walls of Microchannels
title_short A Criterion for the Complete Deposition of Magnetic Beads on the Walls of Microchannels
title_sort criterion for the complete deposition of magnetic beads on the walls of microchannels
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805241/
https://www.ncbi.nlm.nih.gov/pubmed/27007336
http://dx.doi.org/10.1371/journal.pone.0151053
work_keys_str_mv AT pallaresjordi acriterionforthecompletedepositionofmagneticbeadsonthewallsofmicrochannels
AT pallaresjordi criterionforthecompletedepositionofmagneticbeadsonthewallsofmicrochannels