Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3

The major human complement regulator in blood, complement factor H (FH), has several closely related proteins, called FH-related (FHR) proteins. As all FHRs lack relevant complement regulatory activity, their physiological role is not well understood. FHR protein 3 (FHR-3) has been suggested to comp...

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Detalles Bibliográficos
Autores principales: Pouw, Richard B., Brouwer, Mieke C., Geissler, Judy, van Herpen, Laurens V., Zeerleder, Sacha S., Wuillemin, Walter A., Wouters, Diana, Kuijpers, Taco W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805260/
https://www.ncbi.nlm.nih.gov/pubmed/27007437
http://dx.doi.org/10.1371/journal.pone.0152164

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