The Use of Low-Dose Recombinant Tissue Plasminogen Activator to Treat a Preterm Infant with an Intrauterine Spontaneous Arterial Thromboembolism

Neonatal thromboembolic events are rare, and only a few cases of intrauterine spontaneous arterial thromboembolisms have been reported in the literature. Thrombolytic therapy with recombinant tissue plasminogen activator is usually the preferred treatment because it has a short half-life, fewer syst...

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Autores principales: Demirelli, Yaşar, Tekgündüz, Kadir Şerafettin, Caner, İbrahim, Kara, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805322/
https://www.ncbi.nlm.nih.gov/pubmed/26377159
http://dx.doi.org/10.4274/tjh.2015.0016
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author Demirelli, Yaşar
Tekgündüz, Kadir Şerafettin
Caner, İbrahim
Kara, Mustafa
author_facet Demirelli, Yaşar
Tekgündüz, Kadir Şerafettin
Caner, İbrahim
Kara, Mustafa
author_sort Demirelli, Yaşar
collection PubMed
description Neonatal thromboembolic events are rare, and only a few cases of intrauterine spontaneous arterial thromboembolisms have been reported in the literature. Thrombolytic therapy with recombinant tissue plasminogen activator is usually the preferred treatment because it has a short half-life, fewer systemic side effects, and a strong, specific affinity for fibrin. Protocols vary from center to center, but there is still no consensus regarding the proper dosage or treatment duration. Herein, we present the case of an intrauterine spontaneous arterial thromboembolism in a preterm infant that completely resolved after being treated with low-dose recombinant tissue plasminogen activator (0.02 mg/kg/h).
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spelling pubmed-48053222016-04-06 The Use of Low-Dose Recombinant Tissue Plasminogen Activator to Treat a Preterm Infant with an Intrauterine Spontaneous Arterial Thromboembolism Demirelli, Yaşar Tekgündüz, Kadir Şerafettin Caner, İbrahim Kara, Mustafa Turk J Haematol Case Report Neonatal thromboembolic events are rare, and only a few cases of intrauterine spontaneous arterial thromboembolisms have been reported in the literature. Thrombolytic therapy with recombinant tissue plasminogen activator is usually the preferred treatment because it has a short half-life, fewer systemic side effects, and a strong, specific affinity for fibrin. Protocols vary from center to center, but there is still no consensus regarding the proper dosage or treatment duration. Herein, we present the case of an intrauterine spontaneous arterial thromboembolism in a preterm infant that completely resolved after being treated with low-dose recombinant tissue plasminogen activator (0.02 mg/kg/h). Galenos Publishing 2015-12 2015-12-03 /pmc/articles/PMC4805322/ /pubmed/26377159 http://dx.doi.org/10.4274/tjh.2015.0016 Text en © Turkish Journal of Hematology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Demirelli, Yaşar
Tekgündüz, Kadir Şerafettin
Caner, İbrahim
Kara, Mustafa
The Use of Low-Dose Recombinant Tissue Plasminogen Activator to Treat a Preterm Infant with an Intrauterine Spontaneous Arterial Thromboembolism
title The Use of Low-Dose Recombinant Tissue Plasminogen Activator to Treat a Preterm Infant with an Intrauterine Spontaneous Arterial Thromboembolism
title_full The Use of Low-Dose Recombinant Tissue Plasminogen Activator to Treat a Preterm Infant with an Intrauterine Spontaneous Arterial Thromboembolism
title_fullStr The Use of Low-Dose Recombinant Tissue Plasminogen Activator to Treat a Preterm Infant with an Intrauterine Spontaneous Arterial Thromboembolism
title_full_unstemmed The Use of Low-Dose Recombinant Tissue Plasminogen Activator to Treat a Preterm Infant with an Intrauterine Spontaneous Arterial Thromboembolism
title_short The Use of Low-Dose Recombinant Tissue Plasminogen Activator to Treat a Preterm Infant with an Intrauterine Spontaneous Arterial Thromboembolism
title_sort use of low-dose recombinant tissue plasminogen activator to treat a preterm infant with an intrauterine spontaneous arterial thromboembolism
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805322/
https://www.ncbi.nlm.nih.gov/pubmed/26377159
http://dx.doi.org/10.4274/tjh.2015.0016
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