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Orchestrating A/P and D/V guidance - A Wnt/Netrin tale

While ample information was gathered in identifying guidance cues and their downstream mediators, very little is known about how the information from multiple extracellular cues is intracellularly to generate normal patterning. Netrin and Wnt signaling pathways play key roles in normal development a...

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Autor principal: Levy-Strumpf, Naomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805361/
https://www.ncbi.nlm.nih.gov/pubmed/27073738
http://dx.doi.org/10.1080/21624054.2016.1146857
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author Levy-Strumpf, Naomi
author_facet Levy-Strumpf, Naomi
author_sort Levy-Strumpf, Naomi
collection PubMed
description While ample information was gathered in identifying guidance cues and their downstream mediators, very little is known about how the information from multiple extracellular cues is intracellularly to generate normal patterning. Netrin and Wnt signaling pathways play key roles in normal development as well as in malignancies. In C. elegans, as in vertebrates, dorso-ventral (D/V) graded distributions of UNC-6/Netrin and antero-posterior (A/P) graded distributions of Wnts provide instructive polarity information to guide cells and axons along their respective gradients. In this commentary, I will discuss recent findings demonstrating that these 2 signaling pathways also function redundantly to regulate polarity orthogonal to the axis of their gradation. Thus, Wnt signaling components contribute to D/V polarity, while Netrin signaling components contribute to A/P polarity and their joint action collaboratively governs migratory transitions from one axis to the other. These findings pave the way to unraveling broader roles of Wnt and Netrin signaling pathways, roles that are masked due to their redundant nature, and provide a conceptually novel view of how antero-posterior and dorso-ventral guidance mechanisms are orchestrated to establish polarity in multiple biological processes.
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spelling pubmed-48053612016-04-12 Orchestrating A/P and D/V guidance - A Wnt/Netrin tale Levy-Strumpf, Naomi Worm Commentary While ample information was gathered in identifying guidance cues and their downstream mediators, very little is known about how the information from multiple extracellular cues is intracellularly to generate normal patterning. Netrin and Wnt signaling pathways play key roles in normal development as well as in malignancies. In C. elegans, as in vertebrates, dorso-ventral (D/V) graded distributions of UNC-6/Netrin and antero-posterior (A/P) graded distributions of Wnts provide instructive polarity information to guide cells and axons along their respective gradients. In this commentary, I will discuss recent findings demonstrating that these 2 signaling pathways also function redundantly to regulate polarity orthogonal to the axis of their gradation. Thus, Wnt signaling components contribute to D/V polarity, while Netrin signaling components contribute to A/P polarity and their joint action collaboratively governs migratory transitions from one axis to the other. These findings pave the way to unraveling broader roles of Wnt and Netrin signaling pathways, roles that are masked due to their redundant nature, and provide a conceptually novel view of how antero-posterior and dorso-ventral guidance mechanisms are orchestrated to establish polarity in multiple biological processes. Taylor & Francis 2016-02-06 /pmc/articles/PMC4805361/ /pubmed/27073738 http://dx.doi.org/10.1080/21624054.2016.1146857 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Levy-Strumpf, Naomi
Orchestrating A/P and D/V guidance - A Wnt/Netrin tale
title Orchestrating A/P and D/V guidance - A Wnt/Netrin tale
title_full Orchestrating A/P and D/V guidance - A Wnt/Netrin tale
title_fullStr Orchestrating A/P and D/V guidance - A Wnt/Netrin tale
title_full_unstemmed Orchestrating A/P and D/V guidance - A Wnt/Netrin tale
title_short Orchestrating A/P and D/V guidance - A Wnt/Netrin tale
title_sort orchestrating a/p and d/v guidance - a wnt/netrin tale
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805361/
https://www.ncbi.nlm.nih.gov/pubmed/27073738
http://dx.doi.org/10.1080/21624054.2016.1146857
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