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Orchestrating A/P and D/V guidance - A Wnt/Netrin tale
While ample information was gathered in identifying guidance cues and their downstream mediators, very little is known about how the information from multiple extracellular cues is intracellularly to generate normal patterning. Netrin and Wnt signaling pathways play key roles in normal development a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805361/ https://www.ncbi.nlm.nih.gov/pubmed/27073738 http://dx.doi.org/10.1080/21624054.2016.1146857 |
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author | Levy-Strumpf, Naomi |
author_facet | Levy-Strumpf, Naomi |
author_sort | Levy-Strumpf, Naomi |
collection | PubMed |
description | While ample information was gathered in identifying guidance cues and their downstream mediators, very little is known about how the information from multiple extracellular cues is intracellularly to generate normal patterning. Netrin and Wnt signaling pathways play key roles in normal development as well as in malignancies. In C. elegans, as in vertebrates, dorso-ventral (D/V) graded distributions of UNC-6/Netrin and antero-posterior (A/P) graded distributions of Wnts provide instructive polarity information to guide cells and axons along their respective gradients. In this commentary, I will discuss recent findings demonstrating that these 2 signaling pathways also function redundantly to regulate polarity orthogonal to the axis of their gradation. Thus, Wnt signaling components contribute to D/V polarity, while Netrin signaling components contribute to A/P polarity and their joint action collaboratively governs migratory transitions from one axis to the other. These findings pave the way to unraveling broader roles of Wnt and Netrin signaling pathways, roles that are masked due to their redundant nature, and provide a conceptually novel view of how antero-posterior and dorso-ventral guidance mechanisms are orchestrated to establish polarity in multiple biological processes. |
format | Online Article Text |
id | pubmed-4805361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-48053612016-04-12 Orchestrating A/P and D/V guidance - A Wnt/Netrin tale Levy-Strumpf, Naomi Worm Commentary While ample information was gathered in identifying guidance cues and their downstream mediators, very little is known about how the information from multiple extracellular cues is intracellularly to generate normal patterning. Netrin and Wnt signaling pathways play key roles in normal development as well as in malignancies. In C. elegans, as in vertebrates, dorso-ventral (D/V) graded distributions of UNC-6/Netrin and antero-posterior (A/P) graded distributions of Wnts provide instructive polarity information to guide cells and axons along their respective gradients. In this commentary, I will discuss recent findings demonstrating that these 2 signaling pathways also function redundantly to regulate polarity orthogonal to the axis of their gradation. Thus, Wnt signaling components contribute to D/V polarity, while Netrin signaling components contribute to A/P polarity and their joint action collaboratively governs migratory transitions from one axis to the other. These findings pave the way to unraveling broader roles of Wnt and Netrin signaling pathways, roles that are masked due to their redundant nature, and provide a conceptually novel view of how antero-posterior and dorso-ventral guidance mechanisms are orchestrated to establish polarity in multiple biological processes. Taylor & Francis 2016-02-06 /pmc/articles/PMC4805361/ /pubmed/27073738 http://dx.doi.org/10.1080/21624054.2016.1146857 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Commentary Levy-Strumpf, Naomi Orchestrating A/P and D/V guidance - A Wnt/Netrin tale |
title | Orchestrating A/P and D/V guidance - A Wnt/Netrin tale |
title_full | Orchestrating A/P and D/V guidance - A Wnt/Netrin tale |
title_fullStr | Orchestrating A/P and D/V guidance - A Wnt/Netrin tale |
title_full_unstemmed | Orchestrating A/P and D/V guidance - A Wnt/Netrin tale |
title_short | Orchestrating A/P and D/V guidance - A Wnt/Netrin tale |
title_sort | orchestrating a/p and d/v guidance - a wnt/netrin tale |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805361/ https://www.ncbi.nlm.nih.gov/pubmed/27073738 http://dx.doi.org/10.1080/21624054.2016.1146857 |
work_keys_str_mv | AT levystrumpfnaomi orchestratingapanddvguidanceawntnetrintale |