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Restrictive pattern on spirometry: association with cardiovascular risk and level of physical activity in asymptomatic adults
OBJECTIVE: : To determine whether a restrictive pattern on spirometry is associated with the level of physical activity in daily life (PADL), as well as with cardiovascular disease (CVD) risk factors, in asymptomatic adults. METHODS: : A total of 374 participants (mean age, 41 ± 14 years) underwent...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Pneumologia e Tisiologia
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805383/ https://www.ncbi.nlm.nih.gov/pubmed/26982037 http://dx.doi.org/10.1590/S1806-37562016000000030 |
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author | Sperandio, Evandro Fornias Arantes, Rodolfo Leite Matheus, Agatha Caveda da Silva, Rodrigo Pereira Lauria, Vinícius Tonon Romiti, Marcello Gagliardi, Antônio Ricardo de Toledo Dourado, Victor Zuniga |
author_facet | Sperandio, Evandro Fornias Arantes, Rodolfo Leite Matheus, Agatha Caveda da Silva, Rodrigo Pereira Lauria, Vinícius Tonon Romiti, Marcello Gagliardi, Antônio Ricardo de Toledo Dourado, Victor Zuniga |
author_sort | Sperandio, Evandro Fornias |
collection | PubMed |
description | OBJECTIVE: : To determine whether a restrictive pattern on spirometry is associated with the level of physical activity in daily life (PADL), as well as with cardiovascular disease (CVD) risk factors, in asymptomatic adults. METHODS: : A total of 374 participants (mean age, 41 ± 14 years) underwent spirometry, which included the determination of FVC and FEV(1). A restrictive pattern on spirometry was defined as an FEV(1)/FVC ratio > 0.7 and an FVC < 80% of the predicted value. After conducting demographic, anthropometric, and CVD risk assessments, we evaluated body composition, muscle function, and postural balance, as well as performing cardiopulmonary exercise testing and administering the six-minute walk test. The PADL was quantified with a triaxial accelerometer. RESULTS: : A restrictive pattern on spirometry was found in 10% of the subjects. After multivariate logistic regression, adjusted for confounders (PADL and cardiorespiratory fitness), the following variables retained significance (OR; 95% CI) as predictors of a restrictive pattern: systemic arterial hypertension (17.5; 1.65-184.8), smoking (11.6; 1.56-87.5), physical inactivity (8.1; 1.43-46.4), larger center-of-pressure area while standing on a force platform (1.34; 1.05-1.71); and dyslipidemia (1.89; 1.12-1.98). CONCLUSIONS: : A restrictive pattern on spirometry appears to be common in asymptomatic adults. We found that CVD risk factors, especially systemic arterial hypertension, smoking, and physical inactivity, were directly associated with a restrictive pattern, even when the analysis was adjusted for PADL and cardiorespiratory fitness. Longitudinal studies are needed in order to improve understanding of the etiology of a restrictive pattern as well as to aid in the design of preventive strategies. |
format | Online Article Text |
id | pubmed-4805383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-48053832016-04-15 Restrictive pattern on spirometry: association with cardiovascular risk and level of physical activity in asymptomatic adults Sperandio, Evandro Fornias Arantes, Rodolfo Leite Matheus, Agatha Caveda da Silva, Rodrigo Pereira Lauria, Vinícius Tonon Romiti, Marcello Gagliardi, Antônio Ricardo de Toledo Dourado, Victor Zuniga J Bras Pneumol Artigo Original OBJECTIVE: : To determine whether a restrictive pattern on spirometry is associated with the level of physical activity in daily life (PADL), as well as with cardiovascular disease (CVD) risk factors, in asymptomatic adults. METHODS: : A total of 374 participants (mean age, 41 ± 14 years) underwent spirometry, which included the determination of FVC and FEV(1). A restrictive pattern on spirometry was defined as an FEV(1)/FVC ratio > 0.7 and an FVC < 80% of the predicted value. After conducting demographic, anthropometric, and CVD risk assessments, we evaluated body composition, muscle function, and postural balance, as well as performing cardiopulmonary exercise testing and administering the six-minute walk test. The PADL was quantified with a triaxial accelerometer. RESULTS: : A restrictive pattern on spirometry was found in 10% of the subjects. After multivariate logistic regression, adjusted for confounders (PADL and cardiorespiratory fitness), the following variables retained significance (OR; 95% CI) as predictors of a restrictive pattern: systemic arterial hypertension (17.5; 1.65-184.8), smoking (11.6; 1.56-87.5), physical inactivity (8.1; 1.43-46.4), larger center-of-pressure area while standing on a force platform (1.34; 1.05-1.71); and dyslipidemia (1.89; 1.12-1.98). CONCLUSIONS: : A restrictive pattern on spirometry appears to be common in asymptomatic adults. We found that CVD risk factors, especially systemic arterial hypertension, smoking, and physical inactivity, were directly associated with a restrictive pattern, even when the analysis was adjusted for PADL and cardiorespiratory fitness. Longitudinal studies are needed in order to improve understanding of the etiology of a restrictive pattern as well as to aid in the design of preventive strategies. Sociedade Brasileira de Pneumologia e Tisiologia 2016 /pmc/articles/PMC4805383/ /pubmed/26982037 http://dx.doi.org/10.1590/S1806-37562016000000030 Text en http://creativecommons.org/licenses/by-nc/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Artigo Original Sperandio, Evandro Fornias Arantes, Rodolfo Leite Matheus, Agatha Caveda da Silva, Rodrigo Pereira Lauria, Vinícius Tonon Romiti, Marcello Gagliardi, Antônio Ricardo de Toledo Dourado, Victor Zuniga Restrictive pattern on spirometry: association with cardiovascular risk and level of physical activity in asymptomatic adults |
title | Restrictive pattern on spirometry: association with cardiovascular risk and level of physical activity in asymptomatic adults |
title_full | Restrictive pattern on spirometry: association with cardiovascular risk and level of physical activity in asymptomatic adults |
title_fullStr | Restrictive pattern on spirometry: association with cardiovascular risk and level of physical activity in asymptomatic adults |
title_full_unstemmed | Restrictive pattern on spirometry: association with cardiovascular risk and level of physical activity in asymptomatic adults |
title_short | Restrictive pattern on spirometry: association with cardiovascular risk and level of physical activity in asymptomatic adults |
title_sort | restrictive pattern on spirometry: association with cardiovascular risk and level of physical activity in asymptomatic adults |
topic | Artigo Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805383/ https://www.ncbi.nlm.nih.gov/pubmed/26982037 http://dx.doi.org/10.1590/S1806-37562016000000030 |
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