HOXs and lincRNAs: Two sides of the same coin

The clustered Hox genes play fundamental roles in regulation of axial patterning and elaboration of the basic body plan in animal development. There are common features in the organization and regulatory landscape of Hox clusters associated with their highly conserved functional roles. The presence...

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Detalles Bibliográficos
Autores principales: De Kumar, Bony, Krumlauf, Robb
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805430/
https://www.ncbi.nlm.nih.gov/pubmed/27034976
http://dx.doi.org/10.1126/sciadv.1501402
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author De Kumar, Bony
Krumlauf, Robb
author_facet De Kumar, Bony
Krumlauf, Robb
author_sort De Kumar, Bony
collection PubMed
description The clustered Hox genes play fundamental roles in regulation of axial patterning and elaboration of the basic body plan in animal development. There are common features in the organization and regulatory landscape of Hox clusters associated with their highly conserved functional roles. The presence of transcribed noncoding sequences embedded within the vertebrate Hox clusters is providing insight into a new layer of regulatory information associated with Hox genes.
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spelling pubmed-48054302016-03-31 HOXs and lincRNAs: Two sides of the same coin De Kumar, Bony Krumlauf, Robb Sci Adv Reviews The clustered Hox genes play fundamental roles in regulation of axial patterning and elaboration of the basic body plan in animal development. There are common features in the organization and regulatory landscape of Hox clusters associated with their highly conserved functional roles. The presence of transcribed noncoding sequences embedded within the vertebrate Hox clusters is providing insight into a new layer of regulatory information associated with Hox genes. American Association for the Advancement of Science 2016-01-29 /pmc/articles/PMC4805430/ /pubmed/27034976 http://dx.doi.org/10.1126/sciadv.1501402 Text en Copyright © 2016, The Authors http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Reviews
De Kumar, Bony
Krumlauf, Robb
HOXs and lincRNAs: Two sides of the same coin
title HOXs and lincRNAs: Two sides of the same coin
title_full HOXs and lincRNAs: Two sides of the same coin
title_fullStr HOXs and lincRNAs: Two sides of the same coin
title_full_unstemmed HOXs and lincRNAs: Two sides of the same coin
title_short HOXs and lincRNAs: Two sides of the same coin
title_sort hoxs and lincrnas: two sides of the same coin
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805430/
https://www.ncbi.nlm.nih.gov/pubmed/27034976
http://dx.doi.org/10.1126/sciadv.1501402
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AT krumlaufrobb hoxsandlincrnastwosidesofthesamecoin

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