Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

With no approved pharmacological treatment, nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease in Western countries and its worldwide prevalence continues to increase along with the growing obesity epidemic. Here, we show that a high‐fat high‐sucrose (HFHS...

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Detalles Bibliográficos
Autores principales: Gariani, Karim, Menzies, Keir J., Ryu, Dongryeol, Wegner, Casey J., Wang, Xu, Ropelle, Eduardo R., Moullan, Norman, Zhang, Hongbo, Perino, Alessia, Lemos, Vera, Kim, Bohkyung, Park, Young‐Ki, Piersigilli, Alessandra, Pham, Tho X., Yang, Yue, Ku, Chai Siah, Koo, Sung I., Fomitchova, Anna, Cantó, Carlos, Schoonjans, Kristina, Sauve, Anthony A., Lee, Ji‐Young, Auwerx, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Steatohepatitis/Metabolic Liver Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805450/
https://www.ncbi.nlm.nih.gov/pubmed/26404765
http://dx.doi.org/10.1002/hep.28245

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