Cargando…

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

Ribosome stalling during translation can potentially be harmful, and is surveyed by a conserved quality control pathway that targets the associated mRNA and nascent polypeptide chain (NC). In this pathway, the ribosome-associated quality control (RQC) complex promotes the ubiquitylation and degradat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yonashiro, Ryo, Tahara, Erich B, Bengtson, Mario H, Khokhrina, Maria, Lorenz, Holger, Chen, Kai-Chun, Kigoshi-Tansho, Yu, Savas, Jeffrey N, Yates, John R, Kay, Steve A, Craig, Elizabeth A, Mogk, Axel, Bukau, Bernd, Joazeiro, Claudio AP
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805532/ https://www.ncbi.nlm.nih.gov/pubmed/26943317 http://dx.doi.org/10.7554/eLife.11794

Ejemplares similares

The nascent polypeptide in the 60S subunit determines the Rqc2-dependency of ribosomal quality control
por: Mizuno, Masato, et al.
Publicado: (2021)

RqcH and RqcP catalyze processive poly-alanine synthesis in a reconstituted ribosome-associated quality control system
por: Takada, Hiraku, et al.
Publicado: (2021)

Rqc1 and other yeast proteins containing highly positively charged sequences are not targets of the RQC complex
por: Barros, Géssica C., et al.
Publicado: (2021)

RQC helical hairpin in Bloom's syndrome helicase regulates DNA unwinding by dynamically intercepting nascent nucleotides
por: Ma, Jianbing, et al.
Publicado: (2021)

In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing
por: Osuna, Beatriz A, et al.
Publicado: (2017)

DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities
por: Tadokoro, Takashi, et al.
Publicado: (2012)

The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon
por: von der Malsburg, Karina, et al.
Publicado: (2015)

The Ribosome Restrains Molten Globule Formation in Stalled Nascent Flavodoxin
por: Houwman, Joseline A., et al.
Publicado: (2016)

CAT tails drive degradation of stalled polypeptides on and off the ribosome
por: Sitron, Cole S., et al.
Publicado: (2019)

Nascent MSKIK peptide cancels ribosomal stalling by arrest peptides in Escherichia coli
por: Ojima-Kato, Teruyo, et al.
Publicado: (2023)

WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1
por: Sun, Luxi, et al.
Publicado: (2017)

Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel
por: Wilson, Daniel M., et al.
Publicado: (2020)

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
por: Lintner, Nathanael G., et al.
Publicado: (2017)

Computational analysis of nascent peptides that induce ribosome stalling and their proteomic distribution in Saccharomyces cerevisiae
por: Sabi, Renana, et al.
Publicado: (2017)

Folding stabilities of ribosome-bound nascent polypeptides probed by mass spectrometry
por: Tan, Ruiyue, et al.
Publicado: (2023)

Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
por: Lintner, Nathanael G., et al.
Publicado: (2018)

CONTROLLED PROTEOLYSIS OF NASCENT POLYPEPTIDES IN RAT LIVER CELL FRACTIONS : I. Location of the Polypeptides within Ribosomes
por: Blobel, G., et al.
Publicado: (1970)

Membrane-bound ribosomes of myeloma cells. III. The role of the messenger RNA and the nascent polypeptide chain in the binding of ribosomes to membranes
Publicado: (1975)

Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule
por: Li, Wenfei, et al.
Publicado: (2019)

Antiribophorin antibodies inhibit the targeting to the ER membrane of ribosomes containing nascent secretory polypeptides
Publicado: (1990)

Nascent polypeptide chains exit the ribosome in the same relative position in both eucaryotes and procaryotes
Publicado: (1983)

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome
por: Verma, Rati, et al.
Publicado: (2013)

Elongation inhibitors do not prevent the release of puromycylated nascent polypeptide chains from ribosomes
por: Hobson, Benjamin D, et al.
Publicado: (2020)

Ubiquitination of stalled ribosome triggers ribosome-associated quality control
por: Matsuo, Yoshitaka, et al.
Publicado: (2017)

Reverse genetics-based biochemical studies of the ribosomal exit tunnel constriction region in eukaryotic ribosome stalling: spatial allocation of the regulatory nascent peptide at the constriction
por: Takamatsu, Seidai, et al.
Publicado: (2020)

Vms1/Ankzf1 peptidyl-tRNA hydrolase releases nascent chains from stalled ribosomes
por: Verma, Rati, et al.
Publicado: (2018)

Critical 23S rRNA interactions for macrolide-dependent ribosome stalling on the ErmCL nascent peptide chain
por: Koch, Miriam, et al.
Publicado: (2017)

Shaping the Nascent Ribosome: AAA-ATPases in Eukaryotic Ribosome Biogenesis
por: Prattes, Michael, et al.
Publicado: (2019)

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA
por: Ormsby, Angelique R., et al.
Publicado: (2020)

A dual function for chaperones SSB–RAC and the NAC nascent polypeptide–associated complex on ribosomes
por: Koplin, Ansgar, et al.
Publicado: (2010)

In Vitro Reconstitution of Yeast Translation System Capable of Synthesizing Long Polypeptide and Recapitulating Programmed Ribosome Stalling
por: Nagai, Riku, et al.
Publicado: (2021)

Nascent chain dynamics and ribosome interactions within folded ribosome–nascent chain complexes observed by NMR spectroscopy
por: Burridge, Charles, et al.
Publicado: (2021)

Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast
por: Rubio, Angela, et al.
Publicado: (2020)

Cooperativity between the Ribosome-Associated Chaperone Ssb/RAC and the Ubiquitin Ligase Ltn1 in Ubiquitination of Nascent Polypeptides
por: Ghosh, Arnab, et al.
Publicado: (2020)

The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains
por: Knorr, Alexandra G., et al.
Publicado: (2023)

Ubiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagy
por: Ossareh-Nazari, Batool, et al.
Publicado: (2014)

Human NMD ensues independently of stable ribosome stalling
por: Karousis, Evangelos D., et al.
Publicado: (2020)

The deubiquitylase USP9X controls ribosomal stalling
por: Clancy, Anne, et al.
Publicado: (2021)

In vitro Analysis of Stalled Ribosomes Using Puromycin Incorporation
por: Scarpitti, MaKenzie R., et al.
Publicado: (2023)

NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease
por: Martin, Paige B., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d0ifjoekbri9vuqj490epdvsli