MicroRNAs Are Involved in the Development of Morphine-Induced Analgesic Tolerance and Regulate Functionally Relevant Changes in Serpini1

Long-term opioid treatment results in reduced therapeutic efficacy and in turn leads to an increase in the dose required to produce equivalent pain relief and alleviate break-through or insurmountable pain. Altered gene expression is a likely means for inducing long-term neuroadaptations responsible...

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Detalles Bibliográficos
Autores principales: Tapocik, Jenica D., Ceniccola, Kristin, Mayo, Cheryl L., Schwandt, Melanie L., Solomon, Matthew, Wang, Bi-Dar, Luu, Truong V., Olender, Jacqueline, Harrigan, Thomas, Maynard, Thomas M., Elmer, Greg I., Lee, Norman H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805586/
https://www.ncbi.nlm.nih.gov/pubmed/27047334
http://dx.doi.org/10.3389/fnmol.2016.00020

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