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SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions

A hallmark of synaptic specializations is their dependence on highly organized complexes of proteins that interact with each other. The loss or modification of key synaptic proteins directly affects the properties of such networks, ultimately impacting synaptic function. SNAP-25 is a component of th...

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Autores principales: Antonucci, Flavia, Corradini, Irene, Fossati, Giuliana, Tomasoni, Romana, Menna, Elisabetta, Matteoli, Michela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805587/
https://www.ncbi.nlm.nih.gov/pubmed/27047369
http://dx.doi.org/10.3389/fnsyn.2016.00007
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author Antonucci, Flavia
Corradini, Irene
Fossati, Giuliana
Tomasoni, Romana
Menna, Elisabetta
Matteoli, Michela
author_facet Antonucci, Flavia
Corradini, Irene
Fossati, Giuliana
Tomasoni, Romana
Menna, Elisabetta
Matteoli, Michela
author_sort Antonucci, Flavia
collection PubMed
description A hallmark of synaptic specializations is their dependence on highly organized complexes of proteins that interact with each other. The loss or modification of key synaptic proteins directly affects the properties of such networks, ultimately impacting synaptic function. SNAP-25 is a component of the SNARE complex, which is central to synaptic vesicle exocytosis, and, by directly interacting with different calcium channels subunits, it negatively modulates neuronal voltage-gated calcium channels, thus regulating intracellular calcium dynamics. The SNAP-25 gene has been associated with distinct brain diseases, including Attention Deficit Hyperactivity Disorder (ADHD), schizophrenia and bipolar disorder, indicating that the protein may act as a shared biological substrate among different “synaptopathies”. The mechanisms by which alterations in SNAP-25 may concur to these psychiatric diseases are still undefined, although alterations in neurotransmitter release have been indicated as potential causative processes. This review summarizes recent work showing that SNAP-25 not only controls exo/endocytic processes at the presynaptic terminal, but also regulates postsynaptic receptor trafficking, spine morphogenesis, and plasticity, thus opening the possibility that SNAP-25 defects may contribute to psychiatric diseases by impacting not only presynaptic but also postsynaptic functions.
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spelling pubmed-48055872016-04-04 SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions Antonucci, Flavia Corradini, Irene Fossati, Giuliana Tomasoni, Romana Menna, Elisabetta Matteoli, Michela Front Synaptic Neurosci Neuroscience A hallmark of synaptic specializations is their dependence on highly organized complexes of proteins that interact with each other. The loss or modification of key synaptic proteins directly affects the properties of such networks, ultimately impacting synaptic function. SNAP-25 is a component of the SNARE complex, which is central to synaptic vesicle exocytosis, and, by directly interacting with different calcium channels subunits, it negatively modulates neuronal voltage-gated calcium channels, thus regulating intracellular calcium dynamics. The SNAP-25 gene has been associated with distinct brain diseases, including Attention Deficit Hyperactivity Disorder (ADHD), schizophrenia and bipolar disorder, indicating that the protein may act as a shared biological substrate among different “synaptopathies”. The mechanisms by which alterations in SNAP-25 may concur to these psychiatric diseases are still undefined, although alterations in neurotransmitter release have been indicated as potential causative processes. This review summarizes recent work showing that SNAP-25 not only controls exo/endocytic processes at the presynaptic terminal, but also regulates postsynaptic receptor trafficking, spine morphogenesis, and plasticity, thus opening the possibility that SNAP-25 defects may contribute to psychiatric diseases by impacting not only presynaptic but also postsynaptic functions. Frontiers Media S.A. 2016-03-24 /pmc/articles/PMC4805587/ /pubmed/27047369 http://dx.doi.org/10.3389/fnsyn.2016.00007 Text en Copyright © 2016 Antonucci, Corradini, Fossati, Tomasoni, Menna and Matteoli. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Antonucci, Flavia
Corradini, Irene
Fossati, Giuliana
Tomasoni, Romana
Menna, Elisabetta
Matteoli, Michela
SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions
title SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions
title_full SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions
title_fullStr SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions
title_full_unstemmed SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions
title_short SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions
title_sort snap-25, a known presynaptic protein with emerging postsynaptic functions
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805587/
https://www.ncbi.nlm.nih.gov/pubmed/27047369
http://dx.doi.org/10.3389/fnsyn.2016.00007
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