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Expansion of B-1a Cells with Germline Heavy Chain Sequence in Lupus Mice

B6.Sle1.Sle2.Sle3 (B6.TC) lupus-prone mice carrying the NZB allele of Cdkn2c, encoding for the cyclin-dependent kinase inhibitor P18(INK4), accumulate B-1a cells due to a higher rate of proliferative self-renewal. However, it is unclear whether this affects primarily early-appearing B-1a cells of fe...

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Detalles Bibliográficos
Autores principales:	Holodick, Nichol E., Zeumer, Leilani, Rothstein, Thomas L., Morel, Laurence
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805591/ https://www.ncbi.nlm.nih.gov/pubmed/27047495 http://dx.doi.org/10.3389/fimmu.2016.00108

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