Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors

Parasitic diseases cause ∼500,000 deaths annually and remain a major challenge for therapeutic development. Using a rational design based approach, we developed peptide inhibitors with anti-parasitic activity that were derived from the sequences of parasite scaffold proteins LACK (Leishmania's...

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Detalles Bibliográficos
Autores principales: Qvit, Nir, Schechtman, Deborah, Pena, Darlene Aparecida, Berti, Denise Aparecida, Soares, Chrislaine Oliveira, Miao, Qianqian, Liang, Liying (Annie), Baron, Lauren A., Teh-Poot, Christian, Martínez-Vega, Pedro, Ramirez-Sierra, Maria Jesus, Churchill, Eric, Cunningham, Anna D., Malkovskiy, Andrey V., Federspiel, Nancy A., Gozzo, Fabio Cesar, Torrecilhas, Ana Claudia, Manso Alves, Maria Julia, Jardim, Armando, Momar, Ndao, Dumonteil, Eric, Mochly-Rosen, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805777/
https://www.ncbi.nlm.nih.gov/pubmed/27054066
http://dx.doi.org/10.1016/j.ijpddr.2016.02.003

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