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Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages
We screened a collection of synthetic compounds consisting of natural-product-like substructural motifs to identify a spirocyclic chromane as a novel antiplasmodial pharmacophore using an unbiased cell-based assay. The most active spirocyclic compound UCF 201 exhibits a 50% effective concentration (...
Autores principales: | Roberts, Bracken F., Iyamu, Iredia D., Lee, Sukjun, Lee, Eunyoung, Ayong, Lawrence, Kyle, Dennis E., Yuan, Yu, Manetsch, Roman, Chakrabarti, Debopam |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805781/ https://www.ncbi.nlm.nih.gov/pubmed/27054067 http://dx.doi.org/10.1016/j.ijpddr.2016.02.004 |
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