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Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages

We screened a collection of synthetic compounds consisting of natural-product-like substructural motifs to identify a spirocyclic chromane as a novel antiplasmodial pharmacophore using an unbiased cell-based assay. The most active spirocyclic compound UCF 201 exhibits a 50% effective concentration (...

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Detalles Bibliográficos
Autores principales: Roberts, Bracken F., Iyamu, Iredia D., Lee, Sukjun, Lee, Eunyoung, Ayong, Lawrence, Kyle, Dennis E., Yuan, Yu, Manetsch, Roman, Chakrabarti, Debopam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805781/
https://www.ncbi.nlm.nih.gov/pubmed/27054067
http://dx.doi.org/10.1016/j.ijpddr.2016.02.004

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