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Spindle Oscillations in Sleep Disorders: A Systematic Review
Measurement of sleep microarchitecture and neural oscillations is an increasingly popular technique for quantifying EEG sleep activity. Many studies have examined sleep spindle oscillations in sleep-disordered adults; however reviews of this literature are scarce. As such, our overarching aim was to...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806273/ https://www.ncbi.nlm.nih.gov/pubmed/27034850 http://dx.doi.org/10.1155/2016/7328725 |
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author | Weiner, Oren M. Dang-Vu, Thien Thanh |
author_facet | Weiner, Oren M. Dang-Vu, Thien Thanh |
author_sort | Weiner, Oren M. |
collection | PubMed |
description | Measurement of sleep microarchitecture and neural oscillations is an increasingly popular technique for quantifying EEG sleep activity. Many studies have examined sleep spindle oscillations in sleep-disordered adults; however reviews of this literature are scarce. As such, our overarching aim was to critically review experimental studies examining sleep spindle activity between adults with and without different sleep disorders. Articles were obtained using a systematic methodology with a priori criteria. Thirty-seven studies meeting final inclusion criteria were reviewed, with studies grouped across three categories: insomnia, hypersomnias, and sleep-related movement disorders (including parasomnias). Studies of patients with insomnia and sleep-disordered breathing were more abundant relative to other diagnoses. All studies were cross-sectional. Studies were largely inconsistent regarding spindle activity differences between clinical and nonclinical groups, with some reporting greater or less activity, while many others reported no group differences. Stark inconsistencies in sample characteristics (e.g., age range and diagnostic criteria) and methods of analysis (e.g., spindle bandwidth selection, visual detection versus digital filtering, absolute versus relative spectral power, and NREM2 versus NREM3) suggest a need for greater use of event-based detection methods and increased research standardization. Hypotheses regarding the clinical and empirical implications of these findings, and suggestions for potential future studies, are also discussed. |
format | Online Article Text |
id | pubmed-4806273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48062732016-03-31 Spindle Oscillations in Sleep Disorders: A Systematic Review Weiner, Oren M. Dang-Vu, Thien Thanh Neural Plast Review Article Measurement of sleep microarchitecture and neural oscillations is an increasingly popular technique for quantifying EEG sleep activity. Many studies have examined sleep spindle oscillations in sleep-disordered adults; however reviews of this literature are scarce. As such, our overarching aim was to critically review experimental studies examining sleep spindle activity between adults with and without different sleep disorders. Articles were obtained using a systematic methodology with a priori criteria. Thirty-seven studies meeting final inclusion criteria were reviewed, with studies grouped across three categories: insomnia, hypersomnias, and sleep-related movement disorders (including parasomnias). Studies of patients with insomnia and sleep-disordered breathing were more abundant relative to other diagnoses. All studies were cross-sectional. Studies were largely inconsistent regarding spindle activity differences between clinical and nonclinical groups, with some reporting greater or less activity, while many others reported no group differences. Stark inconsistencies in sample characteristics (e.g., age range and diagnostic criteria) and methods of analysis (e.g., spindle bandwidth selection, visual detection versus digital filtering, absolute versus relative spectral power, and NREM2 versus NREM3) suggest a need for greater use of event-based detection methods and increased research standardization. Hypotheses regarding the clinical and empirical implications of these findings, and suggestions for potential future studies, are also discussed. Hindawi Publishing Corporation 2016 2016-03-10 /pmc/articles/PMC4806273/ /pubmed/27034850 http://dx.doi.org/10.1155/2016/7328725 Text en Copyright © 2016 O. M. Weiner and T. T. Dang-Vu. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Weiner, Oren M. Dang-Vu, Thien Thanh Spindle Oscillations in Sleep Disorders: A Systematic Review |
title | Spindle Oscillations in Sleep Disorders: A Systematic Review |
title_full | Spindle Oscillations in Sleep Disorders: A Systematic Review |
title_fullStr | Spindle Oscillations in Sleep Disorders: A Systematic Review |
title_full_unstemmed | Spindle Oscillations in Sleep Disorders: A Systematic Review |
title_short | Spindle Oscillations in Sleep Disorders: A Systematic Review |
title_sort | spindle oscillations in sleep disorders: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806273/ https://www.ncbi.nlm.nih.gov/pubmed/27034850 http://dx.doi.org/10.1155/2016/7328725 |
work_keys_str_mv | AT weinerorenm spindleoscillationsinsleepdisordersasystematicreview AT dangvuthienthanh spindleoscillationsinsleepdisordersasystematicreview |