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The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea

Primary dysmenorrhea (PDM), menstrual pain without an organic cause, is a prevailing problem in women of reproductive age. We previously reported alterations of structure and functional connectivity (FC) in the periaqueductal gray (PAG) of PDM subjects. Given that the brain derived neurotrophic fact...

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Autores principales: Wei, Shyh-Yuh, Chao, Hsiang-Tai, Tu, Cheng-Hao, Lin, Ming-Wei, Li, Wei-Chi, Low, Intan, Shen, Horng-Der, Chen, Li-Fen, Hsieh, Jen-Chuen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806293/
https://www.ncbi.nlm.nih.gov/pubmed/27010666
http://dx.doi.org/10.1038/srep23639
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author Wei, Shyh-Yuh
Chao, Hsiang-Tai
Tu, Cheng-Hao
Lin, Ming-Wei
Li, Wei-Chi
Low, Intan
Shen, Horng-Der
Chen, Li-Fen
Hsieh, Jen-Chuen
author_facet Wei, Shyh-Yuh
Chao, Hsiang-Tai
Tu, Cheng-Hao
Lin, Ming-Wei
Li, Wei-Chi
Low, Intan
Shen, Horng-Der
Chen, Li-Fen
Hsieh, Jen-Chuen
author_sort Wei, Shyh-Yuh
collection PubMed
description Primary dysmenorrhea (PDM), menstrual pain without an organic cause, is a prevailing problem in women of reproductive age. We previously reported alterations of structure and functional connectivity (FC) in the periaqueductal gray (PAG) of PDM subjects. Given that the brain derived neurotrophic factor (BDNF) acts as a pain modulator within the PAG and the BDNF Val66Met polymorphism contributes towards susceptibility to PDM, the present study of imaging genetics set out to investigate the influence of, firstly, the BDNF Val66Met single nucleotide polymorphism and, secondly, the genotype-pain interplays on the descending pain modulatory systems in the context of PAG-seeded FC patterning. Fifty-six subjects with PDM and 60 controls participated in the current study of resting-state functional magnetic resonance imaging (fMRI) during the menstruation and peri-ovulatory phases; in parallel, blood samples were taken for genotyping. Our findings indicate that the BDNF Val66Met polymorphism is associated with the diverse functional expressions of the descending pain modulatory systems. Furthermore, PAG FC patterns in pain-free controls are altered in women with PDM in a genotype-specific manner. Such resilient brain dynamics may underpin the individual differences and shed light on the vulnerability for chronic pain disorders of PDM subjects.
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spelling pubmed-48062932016-03-24 The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea Wei, Shyh-Yuh Chao, Hsiang-Tai Tu, Cheng-Hao Lin, Ming-Wei Li, Wei-Chi Low, Intan Shen, Horng-Der Chen, Li-Fen Hsieh, Jen-Chuen Sci Rep Article Primary dysmenorrhea (PDM), menstrual pain without an organic cause, is a prevailing problem in women of reproductive age. We previously reported alterations of structure and functional connectivity (FC) in the periaqueductal gray (PAG) of PDM subjects. Given that the brain derived neurotrophic factor (BDNF) acts as a pain modulator within the PAG and the BDNF Val66Met polymorphism contributes towards susceptibility to PDM, the present study of imaging genetics set out to investigate the influence of, firstly, the BDNF Val66Met single nucleotide polymorphism and, secondly, the genotype-pain interplays on the descending pain modulatory systems in the context of PAG-seeded FC patterning. Fifty-six subjects with PDM and 60 controls participated in the current study of resting-state functional magnetic resonance imaging (fMRI) during the menstruation and peri-ovulatory phases; in parallel, blood samples were taken for genotyping. Our findings indicate that the BDNF Val66Met polymorphism is associated with the diverse functional expressions of the descending pain modulatory systems. Furthermore, PAG FC patterns in pain-free controls are altered in women with PDM in a genotype-specific manner. Such resilient brain dynamics may underpin the individual differences and shed light on the vulnerability for chronic pain disorders of PDM subjects. Nature Publishing Group 2016-03-24 /pmc/articles/PMC4806293/ /pubmed/27010666 http://dx.doi.org/10.1038/srep23639 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wei, Shyh-Yuh
Chao, Hsiang-Tai
Tu, Cheng-Hao
Lin, Ming-Wei
Li, Wei-Chi
Low, Intan
Shen, Horng-Der
Chen, Li-Fen
Hsieh, Jen-Chuen
The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea
title The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea
title_full The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea
title_fullStr The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea
title_full_unstemmed The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea
title_short The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea
title_sort bdnf val66met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806293/
https://www.ncbi.nlm.nih.gov/pubmed/27010666
http://dx.doi.org/10.1038/srep23639
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