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A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer's disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for die...

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Autores principales: Wiesmann, Maximilian, Zerbi, Valerio, Jansen, Diane, Haast, Roy, Lütjohann, Dieter, Broersen, Laus M., Heerschap, Arend, Kiliaan, Amanda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806294/
https://www.ncbi.nlm.nih.gov/pubmed/27034849
http://dx.doi.org/10.1155/2016/6846721
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author Wiesmann, Maximilian
Zerbi, Valerio
Jansen, Diane
Haast, Roy
Lütjohann, Dieter
Broersen, Laus M.
Heerschap, Arend
Kiliaan, Amanda J.
author_facet Wiesmann, Maximilian
Zerbi, Valerio
Jansen, Diane
Haast, Roy
Lütjohann, Dieter
Broersen, Laus M.
Heerschap, Arend
Kiliaan, Amanda J.
author_sort Wiesmann, Maximilian
collection PubMed
description APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer's disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD. We hypothesize that the diet could inhibit AD-like pathologies in apoE4 mice, specifically cerebrovascular and connectivity impairment. Moreover, we evaluated the diet effect on cerebral blood flow (CBF), functional connectivity (FC), gray/white matter integrity, and postsynaptic density in aging apoE4 mice. At 10–12 months, apoE4 mice did not display prominent pathological differences compared to wild-type (WT) mice. However, 16–18-month-old apoE4 mice revealed reduced CBF and accelerated synaptic loss. The diet increased cortical CBF and amount of synapses and improved white matter integrity and FC in both aging apoE4 and WT mice. We demonstrated that protective mechanisms on vascular and synapse health are enhanced by Fortasyn, independent of apoE genotype. We further showed the efficacy of a multimodal translational approach, including advanced MR neuroimaging, to study dietary intervention on brain structure and function in aging.
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spelling pubmed-48062942016-03-31 A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice Wiesmann, Maximilian Zerbi, Valerio Jansen, Diane Haast, Roy Lütjohann, Dieter Broersen, Laus M. Heerschap, Arend Kiliaan, Amanda J. Neural Plast Research Article APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer's disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD. We hypothesize that the diet could inhibit AD-like pathologies in apoE4 mice, specifically cerebrovascular and connectivity impairment. Moreover, we evaluated the diet effect on cerebral blood flow (CBF), functional connectivity (FC), gray/white matter integrity, and postsynaptic density in aging apoE4 mice. At 10–12 months, apoE4 mice did not display prominent pathological differences compared to wild-type (WT) mice. However, 16–18-month-old apoE4 mice revealed reduced CBF and accelerated synaptic loss. The diet increased cortical CBF and amount of synapses and improved white matter integrity and FC in both aging apoE4 and WT mice. We demonstrated that protective mechanisms on vascular and synapse health are enhanced by Fortasyn, independent of apoE genotype. We further showed the efficacy of a multimodal translational approach, including advanced MR neuroimaging, to study dietary intervention on brain structure and function in aging. Hindawi Publishing Corporation 2016 2016-03-10 /pmc/articles/PMC4806294/ /pubmed/27034849 http://dx.doi.org/10.1155/2016/6846721 Text en Copyright © 2016 Maximilian Wiesmann et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wiesmann, Maximilian
Zerbi, Valerio
Jansen, Diane
Haast, Roy
Lütjohann, Dieter
Broersen, Laus M.
Heerschap, Arend
Kiliaan, Amanda J.
A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
title A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
title_full A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
title_fullStr A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
title_full_unstemmed A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
title_short A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
title_sort dietary treatment improves cerebral blood flow and brain connectivity in aging apoe4 mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806294/
https://www.ncbi.nlm.nih.gov/pubmed/27034849
http://dx.doi.org/10.1155/2016/6846721
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