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A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer's disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for die...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806294/ https://www.ncbi.nlm.nih.gov/pubmed/27034849 http://dx.doi.org/10.1155/2016/6846721 |
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author | Wiesmann, Maximilian Zerbi, Valerio Jansen, Diane Haast, Roy Lütjohann, Dieter Broersen, Laus M. Heerschap, Arend Kiliaan, Amanda J. |
author_facet | Wiesmann, Maximilian Zerbi, Valerio Jansen, Diane Haast, Roy Lütjohann, Dieter Broersen, Laus M. Heerschap, Arend Kiliaan, Amanda J. |
author_sort | Wiesmann, Maximilian |
collection | PubMed |
description | APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer's disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD. We hypothesize that the diet could inhibit AD-like pathologies in apoE4 mice, specifically cerebrovascular and connectivity impairment. Moreover, we evaluated the diet effect on cerebral blood flow (CBF), functional connectivity (FC), gray/white matter integrity, and postsynaptic density in aging apoE4 mice. At 10–12 months, apoE4 mice did not display prominent pathological differences compared to wild-type (WT) mice. However, 16–18-month-old apoE4 mice revealed reduced CBF and accelerated synaptic loss. The diet increased cortical CBF and amount of synapses and improved white matter integrity and FC in both aging apoE4 and WT mice. We demonstrated that protective mechanisms on vascular and synapse health are enhanced by Fortasyn, independent of apoE genotype. We further showed the efficacy of a multimodal translational approach, including advanced MR neuroimaging, to study dietary intervention on brain structure and function in aging. |
format | Online Article Text |
id | pubmed-4806294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48062942016-03-31 A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice Wiesmann, Maximilian Zerbi, Valerio Jansen, Diane Haast, Roy Lütjohann, Dieter Broersen, Laus M. Heerschap, Arend Kiliaan, Amanda J. Neural Plast Research Article APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer's disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD. We hypothesize that the diet could inhibit AD-like pathologies in apoE4 mice, specifically cerebrovascular and connectivity impairment. Moreover, we evaluated the diet effect on cerebral blood flow (CBF), functional connectivity (FC), gray/white matter integrity, and postsynaptic density in aging apoE4 mice. At 10–12 months, apoE4 mice did not display prominent pathological differences compared to wild-type (WT) mice. However, 16–18-month-old apoE4 mice revealed reduced CBF and accelerated synaptic loss. The diet increased cortical CBF and amount of synapses and improved white matter integrity and FC in both aging apoE4 and WT mice. We demonstrated that protective mechanisms on vascular and synapse health are enhanced by Fortasyn, independent of apoE genotype. We further showed the efficacy of a multimodal translational approach, including advanced MR neuroimaging, to study dietary intervention on brain structure and function in aging. Hindawi Publishing Corporation 2016 2016-03-10 /pmc/articles/PMC4806294/ /pubmed/27034849 http://dx.doi.org/10.1155/2016/6846721 Text en Copyright © 2016 Maximilian Wiesmann et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wiesmann, Maximilian Zerbi, Valerio Jansen, Diane Haast, Roy Lütjohann, Dieter Broersen, Laus M. Heerschap, Arend Kiliaan, Amanda J. A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice |
title | A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice |
title_full | A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice |
title_fullStr | A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice |
title_full_unstemmed | A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice |
title_short | A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice |
title_sort | dietary treatment improves cerebral blood flow and brain connectivity in aging apoe4 mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806294/ https://www.ncbi.nlm.nih.gov/pubmed/27034849 http://dx.doi.org/10.1155/2016/6846721 |
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