Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states

The anti-diabetic drug, metformin, exerts its action through AMP-activated protein kinase (AMPK), and Sirtuin (Sirt1) signaling. Insulin-like growth factor (IGF)-binding protein 2 (IGFBP-2) prevents IGF-1 binding to its receptors, thereby contributing to modulate insulin sensitivity. In this study,...

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Detalles Bibliográficos
Autores principales: Kang, Hye Suk, Cho, Ho-Chan, Lee, Jae-Ho, Oh, Goo Taeg, Koo, Seung-Hoi, Park, Byung-Hyun, Lee, In-Kyu, Choi, Hueng-Sik, Song, Dae-Kyu, Im, Seung-Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806307/
https://www.ncbi.nlm.nih.gov/pubmed/27009398
http://dx.doi.org/10.1038/srep23665

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