Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei

BACKGROUND: Poly(ADP-ribose) (PAR) metabolism participates in several biological processes such as DNA damage signaling and repair, which is a thoroughly studied function. PAR is synthesized by Poly(ADP-ribose) polymerase (PARP) and hydrolyzed by Poly(ADP-ribose) glycohydrolase (PARG). In contrast t...

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Detalles Bibliográficos
Autores principales: Schlesinger, Mariana, Vilchez Larrea, Salomé C., Haikarainen, Teemu, Narwal, Mohit, Venkannagari, Harikanth, Flawiá, Mirtha M., Lehtiö, Lari, Fernández Villamil, Silvia H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806436/
https://www.ncbi.nlm.nih.gov/pubmed/27007296
http://dx.doi.org/10.1186/s13071-016-1461-1

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