The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells

BACKGROUND: Inflammatory breast cancer (IBC) is an aggressive type of advanced breast cancer with a poor prognosis. We recently found that focal adhesion kinase 1 (FAK1) is upregulated and phosphorylated (active) in IBC. In this study, we investigated the effect of CEP-37440, a dual inhibitor of FAK...

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Detalles Bibliográficos
Autores principales: Salem, Israa, Alsalahi, Manal, Chervoneva, Inna, Aburto, Lucy D., Addya, Sankar, Ott, Gregory R., Ruggeri, Bruce A., Cristofanilli, Massimo, Fernandez, Sandra V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806466/
https://www.ncbi.nlm.nih.gov/pubmed/27009091
http://dx.doi.org/10.1186/s13058-016-0694-4

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