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C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury

BACKGROUND: C1q represents the initiating protein of the classical complement cascade, however recent findings indicate pathway independent roles such as developmental pruning of retinal ganglion cell (RGC) axons. Furthermore, chronic neuroinflammation, including increased expression of C1q and acti...

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Detalles Bibliográficos
Autores principales:	Silverman, Sean M., Kim, Byung-Jin, Howell, Garreth R., Miller, Joselyn, John, Simon W. M., Wordinger, Robert J., Clark, Abbot F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806521/ https://www.ncbi.nlm.nih.gov/pubmed/27008854 http://dx.doi.org/10.1186/s13024-016-0089-0

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