Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients

Methadone maintenance treatment (MMT) is commonly used for controlling opioid dependence, preventing withdrawal symptoms, and improving the quality of life of heroin-dependent patients. A steady-state plasma concentration of methadone enantiomers, a measure of methadone metabolism, is an index of tr...

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Detalles Bibliográficos
Autores principales: Yang, Hsin-Chou, Chu, Shih-Kai, Huang, Chieh-Liang, Kuo, Hsiang-Wei, Wang, Sheng-Chang, Liu, Sheng-Wen, Ho, Ing-Kang, Liu, Yu-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806848/
https://www.ncbi.nlm.nih.gov/pubmed/27010727
http://dx.doi.org/10.1371/journal.pgen.1005910

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