Protease-Activated Receptor 4 Induces Bladder Pain through High Mobility Group Box-1

Pain is the significant presenting symptom in Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS). Activation of urothelial protease activated receptor 4 (PAR4) causes pain through release of urothelial macrophage migration inhibitory factor (MIF). High Mobility Group Box-1 (HMGB1), a chromatin-...

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Detalles Bibliográficos
Autores principales: Kouzoukas, Dimitrios E., Ma, Fei, Meyer-Siegler, Katherine L., Westlund, Karin N., Hunt, David E., Vera, Pedro L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806866/
https://www.ncbi.nlm.nih.gov/pubmed/27010488
http://dx.doi.org/10.1371/journal.pone.0152055

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