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Reconciling Longitudinal Naive T-Cell and TREC Dynamics during HIV-1 Infection
Naive T cells in untreated HIV-1 infected individuals have a reduced T-cell receptor excision circle (TREC) content. Previous mathematical models have suggested that this is due to increased naive T-cell division. It remains unclear, however, how reduced naive TREC contents can be reconciled with a...
Autores principales: | Drylewicz, Julia, Vrisekoop, Nienke, Mugwagwa, Tendai, de Boer, Anne Bregje, Otto, Sigrid A., Hazenberg, Mette D., Tesselaar, Kiki, de Boer, Rob J., Borghans, José A. M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806918/ https://www.ncbi.nlm.nih.gov/pubmed/27010200 http://dx.doi.org/10.1371/journal.pone.0152513 |
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