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Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance

BACKGROUND: Enteroendocrine L-cells synthesise and release the gut hormone glucagon-like peptide-1 (GLP-1) in response to food transit. Deletion of the tumour suppressor kinase LKB1 from proglucagon-expressing cells leads to the generation of intestinal polyps but no change in circulating GLP-1 leve...

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Detalles Bibliográficos
Autores principales:	Sayers, Sophie R., Reimann, Frank, Gribble, Fiona M., Parker, Helen, Zac-Varghese, Sagen, Bloom, Stephen R., Foretz, Marc, Viollet, Benoit, Rutter, Guy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806996/ https://www.ncbi.nlm.nih.gov/pubmed/27010458 http://dx.doi.org/10.1371/journal.pone.0149549

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