Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds

Alzheimer's disease (AD) is a complex age-related neurodegenerative disease. In this review, we carefully detail amyloid-β metabolism and its role in AD. We also consider the various genetic animal models used to evaluate therapeutics. Finally, we consider the role of synthetic and plant-based...

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Autores principales: Singh, Sandeep Kumar, Srivastav, Saurabh, Yadav, Amarish Kumar, Srikrishna, Saripella, Perry, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807045/
https://www.ncbi.nlm.nih.gov/pubmed/27034741
http://dx.doi.org/10.1155/2016/7361613
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author Singh, Sandeep Kumar
Srivastav, Saurabh
Yadav, Amarish Kumar
Srikrishna, Saripella
Perry, George
author_facet Singh, Sandeep Kumar
Srivastav, Saurabh
Yadav, Amarish Kumar
Srikrishna, Saripella
Perry, George
author_sort Singh, Sandeep Kumar
collection PubMed
description Alzheimer's disease (AD) is a complex age-related neurodegenerative disease. In this review, we carefully detail amyloid-β metabolism and its role in AD. We also consider the various genetic animal models used to evaluate therapeutics. Finally, we consider the role of synthetic and plant-based compounds in therapeutics.
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spelling pubmed-48070452016-03-31 Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds Singh, Sandeep Kumar Srivastav, Saurabh Yadav, Amarish Kumar Srikrishna, Saripella Perry, George Oxid Med Cell Longev Review Article Alzheimer's disease (AD) is a complex age-related neurodegenerative disease. In this review, we carefully detail amyloid-β metabolism and its role in AD. We also consider the various genetic animal models used to evaluate therapeutics. Finally, we consider the role of synthetic and plant-based compounds in therapeutics. Hindawi Publishing Corporation 2016 2015-12-28 /pmc/articles/PMC4807045/ /pubmed/27034741 http://dx.doi.org/10.1155/2016/7361613 Text en Copyright © 2016 Sandeep Kumar Singh et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Singh, Sandeep Kumar
Srivastav, Saurabh
Yadav, Amarish Kumar
Srikrishna, Saripella
Perry, George
Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds
title Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds
title_full Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds
title_fullStr Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds
title_full_unstemmed Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds
title_short Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds
title_sort overview of alzheimer's disease and some therapeutic approaches targeting aβ by using several synthetic and herbal compounds
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807045/
https://www.ncbi.nlm.nih.gov/pubmed/27034741
http://dx.doi.org/10.1155/2016/7361613
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