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Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia

Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed that NF-kB-induced Pax7 overexpression impairs the myogenic potential of muscle precursors in cachectic mice, suggesting that lowering Pax7 expression may be beneficial in cancer...

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Autores principales: Coletti, Dario, Aulino, Paola, Pigna, Eva, Barteri, Fabio, Moresi, Viviana, Annibali, Daniela, Adamo, Sergio, Berardi, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807049/
https://www.ncbi.nlm.nih.gov/pubmed/27034684
http://dx.doi.org/10.1155/2016/6729268
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author Coletti, Dario
Aulino, Paola
Pigna, Eva
Barteri, Fabio
Moresi, Viviana
Annibali, Daniela
Adamo, Sergio
Berardi, Emanuele
author_facet Coletti, Dario
Aulino, Paola
Pigna, Eva
Barteri, Fabio
Moresi, Viviana
Annibali, Daniela
Adamo, Sergio
Berardi, Emanuele
author_sort Coletti, Dario
collection PubMed
description Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed that NF-kB-induced Pax7 overexpression impairs the myogenic potential of muscle precursors in cachectic mice, suggesting that lowering Pax7 expression may be beneficial in cancer cachexia. We evaluated the muscle regenerative potential after acute injury in C26 colon carcinoma tumor-bearing mice and healthy controls. Our analyses confirmed that the delayed muscle regeneration observed in muscles form tumor-bearing mice was associated with a persistent local inflammation and Pax7 overexpression. Physical activity is known to exert positive effects on cachectic muscles. However, the mechanism by which a moderate voluntary exercise ameliorates muscle wasting is not fully elucidated. To verify if physical activity affects Pax7 expression, we hosted control and C26-bearing mice in wheel-equipped cages and we found that voluntary wheel running downregulated Pax7 expression in muscles from tumor-bearing mice. As expected, downregulation of Pax7 expression was associated with a rescue of muscle mass and fiber size. Our findings shed light on the molecular basis of the beneficial effect exerted by a moderate physical exercise on muscle stem cells in cancer cachexia. Furthermore, we propose voluntary exercise as a physiological tool to counteract the overexpression of Pax7 observed in cancer cachexia.
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spelling pubmed-48070492016-03-31 Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia Coletti, Dario Aulino, Paola Pigna, Eva Barteri, Fabio Moresi, Viviana Annibali, Daniela Adamo, Sergio Berardi, Emanuele Stem Cells Int Research Article Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed that NF-kB-induced Pax7 overexpression impairs the myogenic potential of muscle precursors in cachectic mice, suggesting that lowering Pax7 expression may be beneficial in cancer cachexia. We evaluated the muscle regenerative potential after acute injury in C26 colon carcinoma tumor-bearing mice and healthy controls. Our analyses confirmed that the delayed muscle regeneration observed in muscles form tumor-bearing mice was associated with a persistent local inflammation and Pax7 overexpression. Physical activity is known to exert positive effects on cachectic muscles. However, the mechanism by which a moderate voluntary exercise ameliorates muscle wasting is not fully elucidated. To verify if physical activity affects Pax7 expression, we hosted control and C26-bearing mice in wheel-equipped cages and we found that voluntary wheel running downregulated Pax7 expression in muscles from tumor-bearing mice. As expected, downregulation of Pax7 expression was associated with a rescue of muscle mass and fiber size. Our findings shed light on the molecular basis of the beneficial effect exerted by a moderate physical exercise on muscle stem cells in cancer cachexia. Furthermore, we propose voluntary exercise as a physiological tool to counteract the overexpression of Pax7 observed in cancer cachexia. Hindawi Publishing Corporation 2016 2015-12-20 /pmc/articles/PMC4807049/ /pubmed/27034684 http://dx.doi.org/10.1155/2016/6729268 Text en Copyright © 2016 Dario Coletti et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Coletti, Dario
Aulino, Paola
Pigna, Eva
Barteri, Fabio
Moresi, Viviana
Annibali, Daniela
Adamo, Sergio
Berardi, Emanuele
Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia
title Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia
title_full Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia
title_fullStr Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia
title_full_unstemmed Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia
title_short Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia
title_sort spontaneous physical activity downregulates pax7 in cancer cachexia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807049/
https://www.ncbi.nlm.nih.gov/pubmed/27034684
http://dx.doi.org/10.1155/2016/6729268
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