Altered Mitochondrial Respiration and Other Features of Mitochondrial Function in Parkin-Mutant Fibroblasts from Parkinson's Disease Patients

Mutations in the parkin gene are the most common cause of early-onset Parkinson's disease (PD). Parkin, an E3 ubiquitin ligase, is involved in respiratory chain function, mitophagy, and mitochondrial dynamics. Human cellular models with parkin null mutations are particularly valuable for invest...

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Detalles Bibliográficos
Autores principales: Haylett, William, Swart, Chrisna, van der Westhuizen, Francois, van Dyk, Hayley, van der Merwe, Lize, van der Merwe, Celia, Loos, Ben, Carr, Jonathan, Kinnear, Craig, Bardien, Soraya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807059/
https://www.ncbi.nlm.nih.gov/pubmed/27034887
http://dx.doi.org/10.1155/2016/1819209

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