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Unnatural amino acid photo-crosslinking of the I(Ks) channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4
Cardiac repolarization is determined in part by the slow delayed rectifier current (I(Ks)), through the tetrameric voltage-gated ion channel, KCNQ1, and its β-subunit, KCNE1. The stoichiometry between α and β-subunits has been controversial with studies reporting either a strict 2 KCNE1:4 KCNQ1 or a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807126/ https://www.ncbi.nlm.nih.gov/pubmed/26802629 http://dx.doi.org/10.7554/eLife.11815 |