Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro

Mesenchymal stem cells (MSCs) are known for their important properties involving multilineage differentiation potential., trophic factor secretion and localization along various organs and tissues. On the dark side, MSCs play a distinguished role in tumor microenvironments by differentiating into tu...

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Detalles Bibliográficos
Autores principales: Bellagamba, Bruno Corrêa, de Abreu, Bianca Regina Ribas, Grivicich, Ivana, Markarian, Carolina Franke, Chem, Eduardo, Camassola, Melissa, Nardi, Nance Beyer, Dihl, Rafael Rodrigues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2016
Materias:
Mutagenesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807379/
https://www.ncbi.nlm.nih.gov/pubmed/27007906
http://dx.doi.org/10.1590/1678-4685-GMB-2015-0057
Descripción
Sumario:Mesenchymal stem cells (MSCs) are known for their important properties involving multilineage differentiation potential., trophic factor secretion and localization along various organs and tissues. On the dark side, MSCs play a distinguished role in tumor microenvironments by differentiating into tumor-associated fibroblasts or supporting tumor growth via distinct mechanisms. Cisplatin (CIS) is a drug widely applied in the treatment of a large number of cancers and is known for its cytotoxic and genotoxic effects, both in vitro and in vivo. Here we assessed the effects of CIS on MSCs and the ovarian cancer cell line OVCAR-3, by MTT and comet assays. Our results demonstrated the resistance of MSCs to cell death and DNA damage induction by CIS, which was not observed when OVCAR-3 cells were exposed to this drug.

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