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IL-12-conditioning improves retrovirally-mediated transduction efficiency of CD8(+) T cells

The ability to genetically modify T cells is a critical component to many immunotherapeutic strategies and research studies. However, the success of these approaches is often limited by transduction efficiency. Since retroviral vectors require cell division for integration, transduction efficiency i...

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Detalles Bibliográficos
Autores principales:	Andrijauskaite, Kristina, Suriano, Samantha, Cloud, Colleen A., Li, Mingli, Kesarwani, Pravin, Stefanik, Leah S., Moxley, Kelly M., Salem, Mohamed L, Garrett-Mayer, Elizabeth, Paulos, Chrystal M., Mehrotra, Shikhar, Kochenderfer, James N., Cole, David J., Rubinstein, Mark P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807400/ https://www.ncbi.nlm.nih.gov/pubmed/26182912 http://dx.doi.org/10.1038/cgt.2015.28

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